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タイトル: Inhalation Administration of Valerena-4,7(11)-diene from Nardostachys chinensis Roots Ameliorates Restraint Stress-Induced Changes in Murine Behavior and Stress-Related Factors
著者: Takemoto, Hiroaki
Omameuda, Yuka
Ito, Michiho  kyouindb  KAKEN_id
Fukuda, Tatsuo
Kaneko, Shuji  kyouindb  KAKEN_id
Akaike, Akinori
Kobayashi, Yoshinori
著者名の別形: 伊藤, 美千穂
キーワード: Nardostachys chinensis
valerena-4,7(11)-diene
anti-stress effect
inhalation
発行日: Jun-2014
出版者: Pharmaceutical Society of Japan
誌名: Biological and Pharmaceutical Bulletin
巻: 37
号: 6
開始ページ: 1050
終了ページ: 1055
抄録: Dried Nardostachys chinensis roots contain sesquiterpenoids that are widely used as herbal tranquilizers. We previously identified the highly sedative sesquiterpenoid valerena-4,7(11)-diene (VLD) from this plant. In the present study, we investigated stress reducing effects of VLD and the associated mechanisms of action. Application of 15-min restraint stresses induced excitatory behaviors in mice. Immobility times in the forced swim test and sleeping times in the pentobarbital sleep test were shortened in the stressed group by 47% and 43%, respectively, compared with the control group. Furthermore, restraint stress increased serum corticosterone levels by 75%, and cerebral serotonin (5-HT) and dopamine (DA) levels. Inhaled VLD (300 µg/cage) suppressed stress-induced excitatory behaviors and significantly reduced stress-induced blood corticosterone, cerebral 5-HT, and DA levels. These results suggest that VLD interacts with the hypothalamic–pituitary–adrenal axis and the sympathetic-adrenomedullary system. These interactions appear to involve GABAergic and D2 antagonist activities. Moreover, tests in anosmic and intravenously treated mice showed that the sedative effect of inhaled VLD was expressed via olfactory stimulation and pulmonary absorption. Although more studies are required to further elucidate the properties of this compound, our studies suggest that VLD may be an effective anti-stress aromatherapy for humans.
著作権等: © 2014 The Pharmaceutical Society of Japan
URI: http://hdl.handle.net/2433/188917
DOI(出版社版): 10.1248/bpb.b14-00136
出現コレクション:学術雑誌掲載論文等

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