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タイトル: | Siphonaxanthin, a green algal carotenoid, as a novel functional compound. |
著者: | Sugawara, Tatsuya https://orcid.org/0000-0002-1203-5521 (unconfirmed) Ganesan, Ponesakki Li, Zhuosi Manabe, Yuki https://orcid.org/0000-0002-5663-0074 (unconfirmed) Hirata, Takashi |
著者名の別形: | 菅原, 達也 |
キーワード: | angiogenesis apoptosis carotenoid inflammation green algae siphonaxanthin |
発行日: | 19-Jun-2014 |
出版者: | MDPI |
誌名: | Marine drugs |
巻: | 12 |
号: | 6 |
開始ページ: | 3660 |
終了ページ: | 3668 |
抄録: | Siphonaxanthin is a specific keto-carotenoid in green algae whose bio-functional properties are yet to be identified. This review focuses on siphonaxanthin as a bioactive compound and outlines the evidence associated with functionality. Siphonaxanthin has been reported to potently inhibit the viability of human leukemia HL-60 cells via induction of apoptosis. In comparison with fucoxanthin, siphonaxanthin markedly reduced cell viability as early as 6 h after treatment. The cellular uptake of siphonaxanthin was 2-fold higher than fucoxanthin. It has been proposed that siphonaxanthin possesses significant anti-angiogenic activity in studies using human umbilical vein endothelial cells and rat aortic ring. The results of these studies suggested that the anti-angiogenic effect of siphonaxanthin is due to the down-regulation of signal transduction by fibroblast growth factor receptor-1 in vascular endothelial cells. Siphonaxanthin also exhibited inhibitory effects on antigen-induced degranulation of mast cells. These findings open up new avenues for future research on siphonaxanthin as a bioactive compound, and additional investigation, especially in vivo studies, are required to validate these findings. In addition, further studies are needed to determine its bioavailability and metabolic fate. |
著作権等: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/189093 |
DOI(出版社版): | 10.3390/md12063660 |
PubMed ID: | 24950294 |
出現コレクション: | 学術雑誌掲載論文等 |
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