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Title: Siphonaxanthin, a green algal carotenoid, as a novel functional compound.
Authors: Sugawara, Tatsuya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1203-5521 (unconfirmed)
Ganesan, Ponesakki
Li, Zhuosi
Manabe, Yuki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-5663-0074 (unconfirmed)
Hirata, Takashi
Author's alias: 菅原, 達也
Keywords: angiogenesis
apoptosis
carotenoid
inflammation
green algae
siphonaxanthin
Issue Date: 19-Jun-2014
Publisher: MDPI
Journal title: Marine drugs
Volume: 12
Issue: 6
Start page: 3660
End page: 3668
Abstract: Siphonaxanthin is a specific keto-carotenoid in green algae whose bio-functional properties are yet to be identified. This review focuses on siphonaxanthin as a bioactive compound and outlines the evidence associated with functionality. Siphonaxanthin has been reported to potently inhibit the viability of human leukemia HL-60 cells via induction of apoptosis. In comparison with fucoxanthin, siphonaxanthin markedly reduced cell viability as early as 6 h after treatment. The cellular uptake of siphonaxanthin was 2-fold higher than fucoxanthin. It has been proposed that siphonaxanthin possesses significant anti-angiogenic activity in studies using human umbilical vein endothelial cells and rat aortic ring. The results of these studies suggested that the anti-angiogenic effect of siphonaxanthin is due to the down-regulation of signal transduction by fibroblast growth factor receptor-1 in vascular endothelial cells. Siphonaxanthin also exhibited inhibitory effects on antigen-induced degranulation of mast cells. These findings open up new avenues for future research on siphonaxanthin as a bioactive compound, and additional investigation, especially in vivo studies, are required to validate these findings. In addition, further studies are needed to determine its bioavailability and metabolic fate.
Rights: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/189093
DOI(Published Version): 10.3390/md12063660
PubMed ID: 24950294
Appears in Collections:Journal Articles

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