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タイトル: Regulation of Energy Homeostasis by GPR41.
著者: Inoue, Daisuke
Tsujimoto, Gozoh
Kimura, Ikuo
著者名の別形: 井上, 大輔
キーワード: GPR41
FFAR3
energy regulation
short-chain fatty acid
gut microbiota
発行日: 26-May-2014
出版者: Frontiers
誌名: Frontiers in endocrinology
巻: 5
論文番号: 81
抄録: Imbalances in energy regulation lead to metabolic disorders such as obesity and diabetes. Diet plays an essential role in the maintenance of body energy homeostasis by acting not only as energy source but also as a signaling modality. Excess energy increases energy expenditure, leading to a consumption of it. In addition to glucose, mammals utilize short-chain fatty acids (SCFAs), which are produced by colonic bacterial fermentation of dietary fiber, as a metabolic fuel. The roles of SCFAs in energy regulation have remained unclear, although the roles of glucose are well-studied. Recently, a G-protein-coupled receptor deorphanizing strategy successfully identified GPR41 (also called free fatty acid receptor 3 or FFAR3) as a receptor for SCFAs. GPR41 is expressed in adipose tissue, gut, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation. In this mini-review, we focus on the role of GPR41 in host energy regulation.
著作権等: © 2014 Inoue, Tsujimoto and Kimura. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
URI: http://hdl.handle.net/2433/189434
DOI(出版社版): 10.3389/fendo.2014.00081
PubMed ID: 24904531
出現コレクション:学術雑誌掲載論文等

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