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Title: Ultrasound induced cancer immunotherapy.
Authors: Unga, Johan
Hashida, Mitsuru  kyouindb  KAKEN_id
Author's alias: 橋田, 充
Issue Date: 15-Jun-2014
Publisher: Elsevier B.V.
Journal title: Advanced drug delivery reviews
Volume: 72
Start page: 144
End page: 153
Abstract: Recently, the use of ultrasound (US) has been shown to have potential in cancer immunotherapy. High intensity focused US destruction of tumors may lead to immunity forming in situ in the body by immune cells being exposed to the tumor debris and immune stimulatory substances that are present in the tumor remains. Another way of achieving anti-cancer immune responses is by using US in combination with microbubbles and nanobubbles to deliver genes and antigens into cells. US leads to bubble destruction and the forces released to direct delivery of the substances into the cytoplasm of the cells thus circumventing the natural barriers. In this way tumor antigens and antigen-encoding genes can be delivered to immune cells and immune response stimulating genes can be delivered to cancer cells thus enhancing immune responses. Combination of bubbles with cell-targeting ligands and US provides an even more sophisticated delivery system whereby the therapy is not only site specific but also cell specific. In this review we describe how US has been used to achieve immunity and discuss the potential and possible obstacles in future development.
Rights: © 2014 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/189523
DOI(Published Version): 10.1016/j.addr.2014.03.004
PubMed ID: 24680708
Appears in Collections:Journal Articles

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