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j.ijpharm.2014.05.037.pdf720.77 kBAdobe PDF見る/開く
タイトル: Preparation of immunostimulatory single-walled carbon nanotube/CpG DNA complexes and evaluation of their potential in cancer immunotherapy.
著者: Zhou, Shuwen
Hashida, Yasuhiko
Kawakami, Shigeru
Mihara, Junya
Umeyama, Tomokazu  kyouindb  KAKEN_id
Imahori, Hiroshi  kyouindb  KAKEN_id
Murakami, Tatsuya
Yamashita, Fumiyoshi  kyouindb  KAKEN_id
Hashida, Mitsuru  kyouindb  KAKEN_id
著者名の別形: 橋田, 充
キーワード: Carbon nanotubes
CpG DNA
Immune activation
Photohyperthermia
Cancer
発行日: 25-Aug-2014
出版者: Elsevier B.V.
誌名: International journal of pharmaceutics
巻: 471
号: 1-2
開始ページ: 214
終了ページ: 223
抄録: Carbon nanotubes (CNTs) have many interesting properties. In particular, their photohyperthermic effect by near-infrared (NIR) irradiation could be used to kill cancer cells, and could thus be applied in photohyperthermic therapy. However, the solubility of CNTs must be improved before they can be used in biological applications. As DNA is reported to disperse the CNTs in aqueous solution with π-π interactions, we hypothesis that immunostimulatory CpG DNA may also disperse the CNTs in aqueous solution. In this study, we used CpG DNA to disperse single-walled CNTs (SWCNTs) in aqueous solution, in order to combine photohyperthermic effect and immunoactivation together to achieve a more effective cancer therapy. As expected, CpG DNA effectively dispersed the SWCNTs in aqueous solution via the formation of SWCNT/CpG DNA complexes. Moreover, the immunoreactivity of the SWCNT/CpG DNA complexes was investigated. The results showed that intratumoral administration of the SWCNT/CpG DNA complexes in mice enhanced the production level of inflammatory cytokines in tumor tissues. Finally, we evaluated the antitumor effects of the SWCNT/CpG DNA complexes in tumor-bearing mice. The result indicated that intratumoral administration of the SWCNT/CpG DNA complexes combined with NIR irradiation was a more effective approach to prevent the proliferation of tumor growth.
著作権等: © 2014 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/189524
DOI(出版社版): 10.1016/j.ijpharm.2014.05.037
PubMed ID: 24861942
出現コレクション:学術雑誌掲載論文等

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