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Title: Cognitive function of patients with adult moyamoya disease.
Authors: Araki, Yoshio
Takagi, Yasushi
Ueda, Keita  kyouindb  KAKEN_id
Ubukata, Shiho  kyouindb  KAKEN_id
Ishida, Junko
Funaki, Takeshi  kyouindb  KAKEN_id
Kikuchi, Takayuki  kyouindb  KAKEN_id
Takahashi, Jun C
Murai, Toshiya
Miyamoto, Susumu
Author's alias: 荒木, 芳生
宮本, 享
Keywords: Moyamoya disease
cognitive impairment
neuropsychologic tests
Issue Date: Aug-2014
Publisher: Elsevier Inc.
Journal title: Journal of stroke and cerebrovascular diseases
Volume: 23
Issue: 7
Start page: 1789
End page: 1794
Abstract: [Background]Neurocognitive impairment is one of several unsolved social issues faced by patients with moyamoya disease. Although efforts have been made to investigate cognitive function using neuropsychologic tasks, generalizability has been limited. Here, in a preliminary study, we used structured neuropsychologic tasks to establish a standardized neuropsychologic assessment for adult moyamoya patients with and without difficulty in social independence. [Methods]Ten patients with neuroradiologically confirmed adult moyamoya disease (3 male, 7 female) participated. Half of all subjects did not have difficulty with social independence (group 1) and the others had (group 2). Group differences were evaluated after basic cognitive abilities and frontal lobe function were tested. [Results]Although the mean age of group 1 was substantially higher than that of group 2, disease duration did not differ significantly between groups. Means scores for intelligence functions including all subtests for basic cognitive abilities were higher in group 1 compared with group 2. Scores from only 2 frontal lobe evaluation tasks (Trail Making Test B and Theory of Mind) were significantly different between groups. [Conclusions]This preliminary study provides a profile of neurocognitive dysfunction in adult patients with moyamoya disease using structured neuropsychologic tasks. A broad range of cognitive functions was disrupted particularly in the patients who had difficulty with social independence. To obtain stronger evidence regarding neurocognitive dysfunction in patients with moyamoya disease, a multicenter prospective study is essential.
Rights: © 2014 National Stroke Association. Published by Elsevier Inc.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.jstrokecerebrovasdis.2014.04.032
PubMed ID: 24957308
Appears in Collections:Journal Articles

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