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タイトル: | Fas deficiency in mice with the Balb/c background induces blepharitis with allergic inflammation and hyper-IgE production in conjunction with severe autoimmune disease. |
著者: | Takahashi, Suzuka Futatsugi-Yumikura, Shizue Fukuoka, Ayumi Yoshimoto, Tomohiro Nakanishi, Kenji Yonehara, Shin |
著者名の別形: | 米原, 伸 |
キーワード: | allergy auto-antibody CD95 eyelid dermatitis lpr |
発行日: | May-2013 |
出版者: | Oxford University Press |
誌名: | International immunology |
巻: | 25 |
号: | 5 |
開始ページ: | 287 |
終了ページ: | 293 |
抄録: | Fas (CD95) is a cell surface death receptor belonging to the tumor necrosis factor receptor superfamily, which mediates apoptosis-inducing signaling when activated by Fas ligand or its agonistic antibody. lpr mice with a loss of apoptosis-inducing function mutation in the Fas gene develop systemic autoimmune disease and lymphadenopathy but not allergic inflammation. In the case of Fas mutations including lpr and knockout (KO), background genes determine the incidence and severity of lymphadenopathy and histopathological manifestation of systemic autoimmunity: MRL-lpr/lpr mice and C57BL/6-lpr/lpr or C57BL/6 Fas KO mice develop severe and minimum disease, respectively. We generated Fas KO mice with the Balb/c background that show severer autoimmune phenotypes than MRL-lpr/lpr mice, such as critical infiltration of mononuclear cells into lung, liver and spleen, elevated serum levels of auto-antibodies and a decreased life span. To our astonishment, Balb/c Fas KO mice spontaneously develop blepharitis with not only autoimmune inflammation with deposition of auto-antibody but also allergic inflammation with infiltration by eosinophils and mast cells and show the capacity to strongly increase serum level of IgE and IgG1 along with their aging. Thus, Fas expression regulates development of not only autoimmune disease but also allergic inflammation. |
著作権等: | © The Japanese Society for Immunology. This is a pre-copyedited, author-produced PDF of an article accepted for publication in "International Immunology" following peer review. The version of record "Suzuka Takahashi, Shizue Futatsugi-Yumikura, Ayumi Fukuoka, Tomohiro Yoshimoto, Kenji Nakanishi, and Shin Yonehara; Fas deficiency in mice with the Balb/c background induces blepharitis with allergic inflammation and hyper-IgE production in conjunction with severe autoimmune disease; Int. Immunol. (2013) 25 (5): 287-293 first published online December 5, 2012; doi:10.1093/intimm/dxs109" is available online at: http://intimm.oxfordjournals.org/content/25/5/287 この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/189754 |
DOI(出版社版): | 10.1093/intimm/dxs109 |
PubMed ID: | 23220580 |
出現コレクション: | 学術雑誌掲載論文等 |
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