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タイトル: | Dynamics of cellular immune responses in the acute phase of dengue virus infection. |
著者: | Yoshida, Tomoyuki Omatsu, Tsutomu Saito, Akatsuki Katakai, Yuko Iwasaki, Yuki Kurosawa, Terue Hamano, Masataka Higashino, Atsunori https://orcid.org/0000-0002-0817-967X (unconfirmed) Nakamura, Shinichiro Takasaki, Tomohiko Yasutomi, Yasuhiro Kurane, Ichiro Akari, Hirofumi https://orcid.org/0000-0003-2166-6015 (unconfirmed) |
著者名の別形: | 吉田, 友教 明里, 宏文 |
発行日: | Jun-2013 |
出版者: | Springer Vienna |
誌名: | Archives of virology |
巻: | 158 |
号: | 6 |
開始ページ: | 1209 |
終了ページ: | 1220 |
抄録: | In this study, we examined the dynamics of cellular immune responses in the acute phase of dengue virus (DENV) infection in a marmoset model. Here, we found that DENV infection in marmosets greatly induced responses of CD4/CD8 central memory T and NKT cells. Interestingly, the strength of the immune response was greater in animals infected with a dengue fever strain than in those infected with a dengue hemorrhagic fever strain of DENV. In contrast, when animals were re-challenged with the same DENV strain used for primary infection, the neutralizing antibody induced appeared to play a critical role in sterilizing inhibition against viral replication, resulting in strong but delayed responses of CD4/CD8 central memory T and NKT cells. The results in this study may help to better understand the dynamics of cellular and humoral immune responses in the control of DENV infection. |
著作権等: | The final publication is available at Springer via http://dx.doi.org/10.1007/s00705-013-1618-6 この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/189758 |
DOI(出版社版): | 10.1007/s00705-013-1618-6 |
PubMed ID: | 23381396 |
出現コレクション: | 学術雑誌掲載論文等 |
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