このアイテムのアクセス数: 152

このアイテムのファイル:
ファイル 記述 サイズフォーマット 
j.jconrel.2013.10.039.pdf1.82 MBAdobe PDF見る/開く
タイトル: Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite.
著者: Hashida, Yasuhiko
Tanaka, Hironori
Zhou, Shuwen
Kawakami, Shigeru
Yamashita, Fumiyoshi  kyouindb  KAKEN_id
Murakami, Tatsuya
Umeyama, Tomokazu  kyouindb  KAKEN_id
Imahori, Hiroshi  kyouindb  KAKEN_id
Hashida, Mitsuru  kyouindb  KAKEN_id
著者名の別形: 橋田, 泰彦
川上, 茂
橋田, 充
キーワード: Single-walled carbon nanotube
Single-walled carbon nanotube–peptide composite
Near-infrared laser irradiation
Tumor ablation
Photothermal cancer therapy
Aqueous dispersibility
発行日: 10-Jan-2014
出版者: Elsevier B.V.
誌名: Journal of controlled release
巻: 173
開始ページ: 59
終了ページ: 66
抄録: Single-walled carbon nanotubes (SWCNTs) are known to have great potential for biomedical applications such as photothermal ablation of tumor cells in combination with near-infrared (NIR) irradiation. In this study, the photothermal activity of a novel SWCNTs composite with a designed peptide having a repeated structure of H-(-Lys-Phe-Lys-Ala-)7-OH [(KFKA)7] against tumor cells was evaluated in vitro and in vivo. The SWCNT-(KFKA)7 composite demonstrated high aqueous dispersibility that enabled SWCNTs to be used in tumor ablation. The NIR irradiation of SWCNT-(KFKA)7 solution resulted in a rapid temperature increase dependent on the SWCNTs concentration up to 50μg/ml. Three minutes of NIR irradiation of a colon 26 or HepG2 cell culture incubated with SWCNT-(KFKA)7 resulted in remarkable cell damage, while that by single treatment with SWCNT-(KFKA)7 or NIR irradiation alone was moderate. The intratumoral injection of SWCNT-(KFKA)7 solution followed by NIR irradiation resulted in a rapid increase of the temperature to 43°C in the subcutaneously inoculated colon 26 tumor based on thermographic observation and remarkable suppression of tumor growth compared with treatment with only SWCNT-(KFKA)7 injection alone or NIR irradiation alone. These results suggest the a great potential of an SWCNT-peptide composite for use in photothermal cancer therapy.
著作権等: © 2013 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/189759
DOI(出版社版): 10.1016/j.jconrel.2013.10.039
PubMed ID: 24211651
出現コレクション:学術雑誌掲載論文等

アイテムの詳細レコードを表示する

Export to RefWorks


出力フォーマット 


このリポジトリに保管されているアイテムはすべて著作権により保護されています。