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dc.contributor.authorHashida, Yasuhikoja
dc.contributor.authorTanaka, Hironorija
dc.contributor.authorZhou, Shuwenja
dc.contributor.authorKawakami, Shigeruja
dc.contributor.authorYamashita, Fumiyoshija
dc.contributor.authorMurakami, Tatsuyaja
dc.contributor.authorUmeyama, Tomokazuja
dc.contributor.authorImahori, Hiroshija
dc.contributor.authorHashida, Mitsuruja
dc.contributor.alternative橋田, 泰彦ja
dc.contributor.alternative川上, 茂ja
dc.contributor.alternative橋田, 充ja
dc.date.accessioned2014-09-22T04:32:25Z-
dc.date.available2014-09-22T04:32:25Z-
dc.date.issued2014-01-10ja
dc.identifier.issn0168-3659ja
dc.identifier.urihttp://hdl.handle.net/2433/189759-
dc.description.abstractSingle-walled carbon nanotubes (SWCNTs) are known to have great potential for biomedical applications such as photothermal ablation of tumor cells in combination with near-infrared (NIR) irradiation. In this study, the photothermal activity of a novel SWCNTs composite with a designed peptide having a repeated structure of H-(-Lys-Phe-Lys-Ala-)7-OH [(KFKA)7] against tumor cells was evaluated in vitro and in vivo. The SWCNT-(KFKA)7 composite demonstrated high aqueous dispersibility that enabled SWCNTs to be used in tumor ablation. The NIR irradiation of SWCNT-(KFKA)7 solution resulted in a rapid temperature increase dependent on the SWCNTs concentration up to 50μg/ml. Three minutes of NIR irradiation of a colon 26 or HepG2 cell culture incubated with SWCNT-(KFKA)7 resulted in remarkable cell damage, while that by single treatment with SWCNT-(KFKA)7 or NIR irradiation alone was moderate. The intratumoral injection of SWCNT-(KFKA)7 solution followed by NIR irradiation resulted in a rapid increase of the temperature to 43°C in the subcutaneously inoculated colon 26 tumor based on thermographic observation and remarkable suppression of tumor growth compared with treatment with only SWCNT-(KFKA)7 injection alone or NIR irradiation alone. These results suggest the a great potential of an SWCNT-peptide composite for use in photothermal cancer therapy.ja
dc.format.mimetypeapplication/pdfja
dc.language.isoengja
dc.publisherElsevier B.V.ja
dc.rights© 2013 Elsevier B.V.ja
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.subjectSingle-walled carbon nanotubeja
dc.subjectSingle-walled carbon nanotube–peptide compositeja
dc.subjectNear-infrared laser irradiationja
dc.subjectTumor ablationja
dc.subjectPhotothermal cancer therapyja
dc.subjectAqueous dispersibilityja
dc.subject.meshAmino Acid Sequenceja
dc.subject.meshAnimalsja
dc.subject.meshAntineoplastic Agents/chemistryja
dc.subject.meshAntineoplastic Agents/therapeutic useja
dc.subject.meshCell Line, Tumorja
dc.subject.meshHep G2 Cellsja
dc.subject.meshHumansja
dc.subject.meshHyperthermia, Induced/methodsja
dc.subject.meshMiceja
dc.subject.meshMolecular Sequence Dataja
dc.subject.meshNanotubes, Carbon/chemistryja
dc.subject.meshNeoplasms/pathologyja
dc.subject.meshNeoplasms/therapyja
dc.subject.meshPeptides/chemistryja
dc.subject.meshPeptides/therapeutic useja
dc.subject.meshPhototherapy/methodsja
dc.titlePhotothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite.ja
dc.type.niitypeJournal Articleja
dc.identifier.ncidAA10458678ja
dc.identifier.jtitleJournal of controlled releaseja
dc.identifier.volume173ja
dc.identifier.spage59ja
dc.identifier.epage66ja
dc.relation.doi10.1016/j.jconrel.2013.10.039ja
dc.textversionauthorja
dc.identifier.pmid24211651ja
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