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j.jconrel.2013.10.039.pdf | 1.82 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Hashida, Yasuhiko | en |
dc.contributor.author | Tanaka, Hironori | en |
dc.contributor.author | Zhou, Shuwen | en |
dc.contributor.author | Kawakami, Shigeru | en |
dc.contributor.author | Yamashita, Fumiyoshi | en |
dc.contributor.author | Murakami, Tatsuya | en |
dc.contributor.author | Umeyama, Tomokazu | en |
dc.contributor.author | Imahori, Hiroshi | en |
dc.contributor.author | Hashida, Mitsuru | en |
dc.contributor.alternative | 橋田, 泰彦 | ja |
dc.contributor.alternative | 川上, 茂 | ja |
dc.contributor.alternative | 橋田, 充 | ja |
dc.date.accessioned | 2014-09-22T04:32:25Z | - |
dc.date.available | 2014-09-22T04:32:25Z | - |
dc.date.issued | 2014-01-10 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/2433/189759 | - |
dc.description.abstract | Single-walled carbon nanotubes (SWCNTs) are known to have great potential for biomedical applications such as photothermal ablation of tumor cells in combination with near-infrared (NIR) irradiation. In this study, the photothermal activity of a novel SWCNTs composite with a designed peptide having a repeated structure of H-(-Lys-Phe-Lys-Ala-)7-OH [(KFKA)7] against tumor cells was evaluated in vitro and in vivo. The SWCNT-(KFKA)7 composite demonstrated high aqueous dispersibility that enabled SWCNTs to be used in tumor ablation. The NIR irradiation of SWCNT-(KFKA)7 solution resulted in a rapid temperature increase dependent on the SWCNTs concentration up to 50μg/ml. Three minutes of NIR irradiation of a colon 26 or HepG2 cell culture incubated with SWCNT-(KFKA)7 resulted in remarkable cell damage, while that by single treatment with SWCNT-(KFKA)7 or NIR irradiation alone was moderate. The intratumoral injection of SWCNT-(KFKA)7 solution followed by NIR irradiation resulted in a rapid increase of the temperature to 43°C in the subcutaneously inoculated colon 26 tumor based on thermographic observation and remarkable suppression of tumor growth compared with treatment with only SWCNT-(KFKA)7 injection alone or NIR irradiation alone. These results suggest the a great potential of an SWCNT-peptide composite for use in photothermal cancer therapy. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2013 Elsevier B.V. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Single-walled carbon nanotube | en |
dc.subject | Single-walled carbon nanotube–peptide composite | en |
dc.subject | Near-infrared laser irradiation | en |
dc.subject | Tumor ablation | en |
dc.subject | Photothermal cancer therapy | en |
dc.subject | Aqueous dispersibility | en |
dc.subject.mesh | Amino Acid Sequence | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Antineoplastic Agents/chemistry | en |
dc.subject.mesh | Antineoplastic Agents/therapeutic use | en |
dc.subject.mesh | Cell Line, Tumor | en |
dc.subject.mesh | Hep G2 Cells | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Hyperthermia, Induced/methods | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Molecular Sequence Data | en |
dc.subject.mesh | Nanotubes, Carbon/chemistry | en |
dc.subject.mesh | Neoplasms/pathology | en |
dc.subject.mesh | Neoplasms/therapy | en |
dc.subject.mesh | Peptides/chemistry | en |
dc.subject.mesh | Peptides/therapeutic use | en |
dc.subject.mesh | Phototherapy/methods | en |
dc.title | Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10458678 | - |
dc.identifier.jtitle | Journal of controlled release | en |
dc.identifier.volume | 173 | - |
dc.identifier.spage | 59 | - |
dc.identifier.epage | 66 | - |
dc.relation.doi | 10.1016/j.jconrel.2013.10.039 | - |
dc.textversion | author | - |
dc.identifier.pmid | 24211651 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0168-3659 | - |
dc.identifier.eissn | 1873-4995 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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