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Title: Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.
Authors: Hou, Zengye
Oishi, Shinya  kyouindb  KAKEN_id  orcid (unconfirmed)
Suzuki, Yamato
Kure, Tatsuhide
Nakanishi, Isao
Hirasawa, Akira  kyouindb  KAKEN_id  orcid (unconfirmed)
Tsujimoto, Gozoh
Ohno, Hiroaki  kyouindb  KAKEN_id  orcid (unconfirmed)
Fujii, Nobutaka
Author's alias: 大野, 浩章
Issue Date: 28-May-2013
Publisher: Royal Society of Chemistry
Journal title: Organic & biomolecular chemistry
Volume: 11
Issue: 20
Start page: 3288
End page: 3296
Abstract: Pyrazolo[4, 3-b]indole derivatives have been designed as novel CK2 inhibitor compounds based on the binding mode analysis of a previously reported phenylpyrazole-type CK2 inhibitor. A series of pyrazolo[4, 3-b]indoles and related dihydropyrazolo[4, 3-b]indoles were efficiently prepared from simple starting materials using a gold-catalysed three-component annulation reaction as a key step. Several of the newly synthesized compounds displayed high levels of inhibitory activity, indicating that the pyrazolo[4, 3-b]indole core represents a promising scaffold for the development of potent CK2 inhibitors.
Rights: This journal is © The Royal Society of Chemistry 2013
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1039/c3ob40223a
PubMed ID: 23535832
Appears in Collections:Journal Articles

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