ダウンロード数: 414
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
c3ob40223a.pdf | 214.65 kB | Adobe PDF | 見る/開く |
タイトル: | Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors. |
著者: | Hou, Zengye Oishi, Shinya https://orcid.org/0000-0002-2833-2539 (unconfirmed) Suzuki, Yamato Kure, Tatsuhide Nakanishi, Isao Hirasawa, Akira https://orcid.org/0000-0001-5692-805X (unconfirmed) Tsujimoto, Gozoh Ohno, Hiroaki https://orcid.org/0000-0002-3246-4809 (unconfirmed) Fujii, Nobutaka |
著者名の別形: | 大野, 浩章 |
発行日: | 28-May-2013 |
出版者: | Royal Society of Chemistry |
誌名: | Organic & biomolecular chemistry |
巻: | 11 |
号: | 20 |
開始ページ: | 3288 |
終了ページ: | 3296 |
抄録: | Pyrazolo[4, 3-b]indole derivatives have been designed as novel CK2 inhibitor compounds based on the binding mode analysis of a previously reported phenylpyrazole-type CK2 inhibitor. A series of pyrazolo[4, 3-b]indoles and related dihydropyrazolo[4, 3-b]indoles were efficiently prepared from simple starting materials using a gold-catalysed three-component annulation reaction as a key step. Several of the newly synthesized compounds displayed high levels of inhibitory activity, indicating that the pyrazolo[4, 3-b]indole core represents a promising scaffold for the development of potent CK2 inhibitors. |
著作権等: | This journal is © The Royal Society of Chemistry 2013 この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/189820 |
DOI(出版社版): | 10.1039/c3ob40223a |
PubMed ID: | 23535832 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。