|Title:||Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.|
Oishi, Shinya https://orcid.org/0000-0002-2833-2539 (unconfirmed)
Hirasawa, Akira https://orcid.org/0000-0001-5692-805X (unconfirmed)
Ohno, Hiroaki https://orcid.org/0000-0002-3246-4809 (unconfirmed)
|Author's alias:||大野, 浩章|
|Publisher:||Royal Society of Chemistry|
|Journal title:||Organic & biomolecular chemistry|
|Abstract:||Pyrazolo[4, 3-b]indole derivatives have been designed as novel CK2 inhibitor compounds based on the binding mode analysis of a previously reported phenylpyrazole-type CK2 inhibitor. A series of pyrazolo[4, 3-b]indoles and related dihydropyrazolo[4, 3-b]indoles were efficiently prepared from simple starting materials using a gold-catalysed three-component annulation reaction as a key step. Several of the newly synthesized compounds displayed high levels of inhibitory activity, indicating that the pyrazolo[4, 3-b]indole core represents a promising scaffold for the development of potent CK2 inhibitors.|
|Rights:||This journal is © The Royal Society of Chemistry 2013|
This is not the published version. Please cite only the published version.
|Appears in Collections:||Journal Articles|
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