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タイトル: Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.
著者: Hou, Zengye
Oishi, Shinya  KAKEN_id  orcid https://orcid.org/0000-0002-2833-2539 (unconfirmed)
Suzuki, Yamato
Kure, Tatsuhide
Nakanishi, Isao
Hirasawa, Akira  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5692-805X (unconfirmed)
Tsujimoto, Gozoh
Ohno, Hiroaki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-3246-4809 (unconfirmed)
Fujii, Nobutaka
著者名の別形: 大野, 浩章
発行日: 28-May-2013
出版者: Royal Society of Chemistry
誌名: Organic & biomolecular chemistry
巻: 11
号: 20
開始ページ: 3288
終了ページ: 3296
抄録: Pyrazolo[4, 3-b]indole derivatives have been designed as novel CK2 inhibitor compounds based on the binding mode analysis of a previously reported phenylpyrazole-type CK2 inhibitor. A series of pyrazolo[4, 3-b]indoles and related dihydropyrazolo[4, 3-b]indoles were efficiently prepared from simple starting materials using a gold-catalysed three-component annulation reaction as a key step. Several of the newly synthesized compounds displayed high levels of inhibitory activity, indicating that the pyrazolo[4, 3-b]indole core represents a promising scaffold for the development of potent CK2 inhibitors.
著作権等: This journal is © The Royal Society of Chemistry 2013
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/189820
DOI(出版社版): 10.1039/c3ob40223a
PubMed ID: 23535832
出現コレクション:学術雑誌掲載論文等

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