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Title: The effectiveness and limitations of triphenyltetrazolium chloride to detect acute myocardial infarction at forensic autopsy.
Authors: Kakimoto, Yu
Tsuruyama, Tatsuaki  kyouindb  KAKEN_id
Miyao, Masashi  kyouindb  KAKEN_id
Abiru, Hitoshi
Sumiyoshi, Shinji
Kotani, Hirokazu  kyouindb  KAKEN_id
Haga, Hironori  kyouindb  KAKEN_id
Tamaki, Keiji  kyouindb  KAKEN_id
Author's alias: 垣本, 由布
玉木, 敬二
Keywords: TTC
myocardial infarction
sudden death
postmortem interval
postmortem diagnosis
Issue Date: Sep-2013
Publisher: Lippincott Williams & Wilkins
Journal title: The American journal of forensic medicine and pathology
Volume: 34
Issue: 3
Start page: 242
End page: 247
Abstract: Triphenyltetrazolium chloride (TTC) is one of the most conventional stains to detect infarcted area of the heart in animal experiments. However, its availability and limitations have not been thoroughly discussed in the forensic field. Here, authors stained human hearts with TTC soon after the harvest. Photographs of the samples were analyzed using image analysis software, which evaluated the occupying ratio of the stained area on the surface of each slice. The results showed that the stainability of TTC declines with the length of the postmortem interval (PMI). Specimens reacted well to TTC within 1.5 days after death and then decreased the stainability logarithmically with PMI (y = - 0.294 In (x) + 1.0441; x = PMI, y = TTC-stained area
total myocardial area, R = 0.5673). Samples with old myocardial infarction produced clear TTC contrast; normal tissue is vivid red, and fibrotic myocardium is white discoloration. In acute myocardial infarction cases where death occurred within 9 hours after the attack, however, the detection of infarcted area was very difficult even when PMI was less than 1.5 days. In summary, the TTC method may be useful within 1.5 days after death, but short suffering period before death disturbs its staining efficiency.
Rights: © 2013 by Lippincott Williams & Wilkins.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/189846
DOI(Published Version): 10.1097/PAF.0b013e31828879cd
PubMed ID: 23949140
Appears in Collections:Journal Articles

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