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dc.contributor.authorKakimoto, Yuja
dc.contributor.authorTsuruyama, Tatsuakija
dc.contributor.authorMiyao, Masashija
dc.contributor.authorAbiru, Hitoshija
dc.contributor.authorSumiyoshi, Shinjija
dc.contributor.authorKotani, Hirokazuja
dc.contributor.authorHaga, Hironorija
dc.contributor.authorTamaki, Keijija
dc.contributor.alternative垣本, 由布ja
dc.contributor.alternative玉木, 敬二ja
dc.date.accessioned2014-09-26T02:26:31Z-
dc.date.available2014-09-26T02:26:31Z-
dc.date.issued2013-09ja
dc.identifier.issn0195-7910ja
dc.identifier.urihttp://hdl.handle.net/2433/189846-
dc.description.abstractTriphenyltetrazolium chloride (TTC) is one of the most conventional stains to detect infarcted area of the heart in animal experiments. However, its availability and limitations have not been thoroughly discussed in the forensic field. Here, authors stained human hearts with TTC soon after the harvest. Photographs of the samples were analyzed using image analysis software, which evaluated the occupying ratio of the stained area on the surface of each slice. The results showed that the stainability of TTC declines with the length of the postmortem interval (PMI). Specimens reacted well to TTC within 1.5 days after death and then decreased the stainability logarithmically with PMI (y = - 0.294 In (x) + 1.0441; x = PMI, y = TTC-stained areaja
dc.description.abstracttotal myocardial area, R = 0.5673). Samples with old myocardial infarction produced clear TTC contrast; normal tissue is vivid red, and fibrotic myocardium is white discoloration. In acute myocardial infarction cases where death occurred within 9 hours after the attack, however, the detection of infarcted area was very difficult even when PMI was less than 1.5 days. In summary, the TTC method may be useful within 1.5 days after death, but short suffering period before death disturbs its staining efficiency.ja
dc.format.mimetypeapplication/pdfja
dc.language.isoengja
dc.publisherLippincott Williams & Wilkinsja
dc.rights© 2013 by Lippincott Williams & Wilkins.ja
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.ja
dc.subjectTTCja
dc.subjectmyocardial infarctionja
dc.subjectsudden deathja
dc.subjectpostmortem intervalja
dc.subjectpostmortem diagnosisja
dc.subject.meshAgedja
dc.subject.meshColoring Agents/diagnostic useja
dc.subject.meshFemaleja
dc.subject.meshFibrosisja
dc.subject.meshForensic Pathologyja
dc.subject.meshHumansja
dc.subject.meshImage Processing, Computer-Assistedja
dc.subject.meshMaleja
dc.subject.meshMiddle Agedja
dc.subject.meshMyocardial Infarction/diagnosisja
dc.subject.meshMyocardium/pathologyja
dc.subject.meshPostmortem Changesja
dc.subject.meshRegression Analysisja
dc.subject.meshStaining and Labelingja
dc.subject.meshTetrazolium Salts/diagnostic useja
dc.subject.meshTime Factorsja
dc.titleThe effectiveness and limitations of triphenyltetrazolium chloride to detect acute myocardial infarction at forensic autopsy.ja
dc.type.niitypeJournal Articleja
dc.identifier.ncidAA00066376ja
dc.identifier.jtitleThe American journal of forensic medicine and pathologyja
dc.identifier.volume34ja
dc.identifier.issue3ja
dc.identifier.spage242ja
dc.identifier.epage247ja
dc.relation.doi10.1097/PAF.0b013e31828879cdja
dc.textversionauthorja
dc.identifier.pmid23949140ja
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