A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.

Kanai, Masashi; Otsuka, Yoshihiko; Otsuka, Kazunori; Sato, Maremi; Nishimura, Takafumi; Mori, Yukiko; Kawaguchi, Michiya; Hatano, Etsuro; Kodama, Yuzo; Matsumoto, Shigemi; Murakami, Yoshiki; Imaizumi, Atsushi; Chiba, Tsutomu; Nishihira, Jun; Shibata, Hiroyuki

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http://hdl.handle.net/2433/189888

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dc.contributor.author	Kanai, Masashi	en
dc.contributor.author	Otsuka, Yoshihiko	en
dc.contributor.author	Otsuka, Kazunori	en
dc.contributor.author	Sato, Maremi	en
dc.contributor.author	Nishimura, Takafumi	en
dc.contributor.author	Mori, Yukiko	en
dc.contributor.author	Kawaguchi, Michiya	en
dc.contributor.author	Hatano, Etsuro	en
dc.contributor.author	Kodama, Yuzo	en
dc.contributor.author	Matsumoto, Shigemi	en
dc.contributor.author	Murakami, Yoshiki	en
dc.contributor.author	Imaizumi, Atsushi	en
dc.contributor.author	Chiba, Tsutomu	en
dc.contributor.author	Nishihira, Jun	en
dc.contributor.author	Shibata, Hiroyuki	en
dc.contributor.alternative	金井, 雅史	ja
dc.date.accessioned	2014-09-30T00:16:51Z	-
dc.date.available	2014-09-30T00:16:51Z	-
dc.date.issued	2013-06	-
dc.identifier.issn	0344-5704	-
dc.identifier.uri	http://hdl.handle.net/2433/189888	-
dc.description.abstract	A growing number of preclinical studies have demonstrated that curcumin could be a promising anticancer drug; however, poor bioavailability has been the major obstacle for its clinical application. To overcome this problem, we developed a new form of curcumin (Theracurmin) and reported high plasma curcumin levels could be safely achieved after a single administration of Theracurmin in healthy volunteers. In this study, we aimed to evaluate the safety of repetitive administration of Theracurmin in cancer patients.	en
dc.format.mimetype	application/pdf	-
dc.language.iso	eng	-
dc.publisher	Springer-Verlag	en
dc.rights	The final publication is available at Springer via http://dx.doi.org/10.1007/s00280-013-2151-8	en
dc.rights	この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。	ja
dc.rights	This is not the published version. Please cite only the published version.	en
dc.subject	Curcumin	en
dc.subject	Bioavailability	en
dc.subject	Theracurmin®	en
dc.subject	Gemcitabine	en
dc.subject	Pancreatic cancer	en
dc.subject.mesh	Aged	en
dc.subject.mesh	Aged, 80 and over	en
dc.subject.mesh	Antineoplastic Combined Chemotherapy Protocols/administration & dosage	en
dc.subject.mesh	Antineoplastic Combined Chemotherapy Protocols/adverse effects	en
dc.subject.mesh	Antineoplastic Combined Chemotherapy Protocols/chemistry	en
dc.subject.mesh	Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics	en
dc.subject.mesh	Biliary Tract Neoplasms/drug therapy	en
dc.subject.mesh	Biliary Tract Neoplasms/metabolism	en
dc.subject.mesh	Biliary Tract Neoplasms/mortality	en
dc.subject.mesh	Biological Availability	en
dc.subject.mesh	Curcumin/administration & dosage	en
dc.subject.mesh	Curcumin/adverse effects	en
dc.subject.mesh	Curcumin/chemistry	en
dc.subject.mesh	Curcumin/pharmacokinetics	en
dc.subject.mesh	Cytokines/antagonists & inhibitors	en
dc.subject.mesh	Cytokines/immunology	en
dc.subject.mesh	Disease-Free Survival	en
dc.subject.mesh	Dose-Response Relationship, Drug	en
dc.subject.mesh	Drug Administration Schedule	en
dc.subject.mesh	Drug Compounding	en
dc.subject.mesh	Drug Stability	en
dc.subject.mesh	Female	en
dc.subject.mesh	Humans	en
dc.subject.mesh	Male	en
dc.subject.mesh	Maximum Tolerated Dose	en
dc.subject.mesh	Middle Aged	en
dc.subject.mesh	NF-kappa B/antagonists & inhibitors	en
dc.subject.mesh	Pancreatic Neoplasms/drug therapy	en
dc.subject.mesh	Pancreatic Neoplasms/metabolism	en
dc.subject.mesh	Pancreatic Neoplasms/mortality	en
dc.subject.mesh	Quality of Life	en
dc.subject.mesh	Solubility	en
dc.title	A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.	en
dc.type	journal article	-
dc.type.niitype	Journal Article	-
dc.identifier.ncid	AA00598397	-
dc.identifier.jtitle	Cancer chemotherapy and pharmacology	en
dc.identifier.volume	71	-
dc.identifier.issue	6	-
dc.identifier.spage	1521	-
dc.identifier.epage	1530	-
dc.relation.doi	10.1007/s00280-013-2151-8	-
dc.textversion	author	-
dc.identifier.pmid	23543271	-
dcterms.accessRights	open access	-
出現コレクション:	学術雑誌掲載論文等

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