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Title: Insular activation during reward anticipation reflects duration of illness in abstinent pathological gamblers
Authors: Tsurumi, Kosuke  kyouindb  KAKEN_id  orcid (unconfirmed)
Kawada, Ryosaku
Yokoyama, Naoto
Sugihara, Genichi  kyouindb  KAKEN_id
Sawamoto, Nobukatsu  kyouindb  KAKEN_id
Aso, Toshihiko  kyouindb  KAKEN_id  orcid (unconfirmed)
Fukuyama, Hidenao
Murai, Toshiya
Takahashi, Hidehiko
Author's alias: 鶴身, 孝介
高橋, 英彦
Issue Date: 9-Sep-2014
Publisher: Frontiers
Journal title: Frontiers in Psychology
Volume: 5
Thesis number: 1013
Abstract: Pathological gambling (PG) is a chronic mental disorder characterized by a difficulty restraining gambling behavior despite negative consequences. Although brain abnormalities in patients with substance use disorders are caused by repetitive drug use and recover partly with drug abstinence, the relationship between brain activity and duration of illness or abstinence of gambling behavior in PG patients remains unclear. Here, using functional magnetic resonance imaging, we compared the brain activity of 23 PG patients recruited from a treatment facility with 27 demographically-matched healthy control subjects during reward anticipation, and examined the correlations between brain activity and duration of illness or abstinence in PG patients. During reward anticipation, PG patients showed decreased activity compared to healthy controls in a broad range of the reward system regions, including the insula cortex. In PG patients, activation in the left insula showed a significant negative correlation with illness duration. Our findings suggest that insular activation during reward anticipation may serve as a marker of progression of pathological gambling.
Rights: © 2014 Tsurumi, Kawada, Yokoyama, Sugihara, Sawamoto, Aso, Fukuyama, Murai and Takahashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI(Published Version): 10.3389/fpsyg.2014.01013
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