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Title: Responses of monkey prefrontal neurons during the execution of transverse patterning
Authors: Nejime, Masafumi
Inoue, Masato
Saruwatari, Masanori
Mikami, Akichika
Nakamura, Katsuki  kyouindb  KAKEN_id
Miyachi, Shigehiro  kyouindb  KAKEN_id
Author's alias: 宮地, 重弘
Keywords: Single neuronal activity
Nonhuman primate
Medial prefrontal cortex
Configural discrimination
Nonlinear association
Long-term memory
Issue Date: Feb-2015
Publisher: Elsevier B.V.
Journal title: Behavioural Brain Research
Volume: 278
Start page: 293
End page: 302
Abstract: Recent functional imaging studies have suggested that the prefrontal cortex (PF) is engaged in the performance of transverse patterning (TP), which consists of 3 conflicting discriminations (A+/B−, B+/C−, C+/A−). However, the roles of PF in TP are still unclear. To address this issue, we examined the neuronal responses in 3 regions [the principal sulcus (PS), dorsal convexity (DC), and medial prefrontal cortex (MPF)] of the macaque PF during the performance of an oculomotor version of TP. A delayed matching-to-sample (DMS) task was used as a control task. The TP task-responsive neurons were most abundant in MPF. We analyzed the dependency of each neuronal response on the task type (TP or DMS), target shape (A, B, or C), and target location (left or right). Immediately after the choice cue presentation, many MPF neurons showed task dependency. Interestingly, some of them already exhibited differential activity between the 2 tasks before the choice cue presentation. Immediately before the saccade, the number of target location-dependent neurons increased in MPF and PS. Among them, many MPF neurons were also influenced by the task type, whereas PS neurons tended to show location dependency without task dependency. These results suggest that MPF and PS are involved in the execution of TP: MPF appears to be more important in the target selection based on the TP rule, whereas PS is apparently more related to the response preparation. In addition, some neurons showed a postsaccadic response, which may be related to the feedback mechanism.
Rights: © 2014 Elsevier B.V.
この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version.
DOI(Published Version): 10.1016/j.bbr.2014.10.015
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