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Title: Fiber tract associated with autistic traits in healthy adults.
Authors: Hirose, Kimito
Miyata, Jun  kyouindb  KAKEN_id
Sugihara, Genichi  kyouindb  KAKEN_id
Kubota, Manabu
Sasamoto, Akihiko
Aso, Toshihiko  kyouindb  KAKEN_id  orcid (unconfirmed)
Fukuyama, Hidenao
Murai, Toshiya
Takahashi, Hidehiko
Author's alias: 廣瀬, 公人
高橋, 英彦
Keywords: Autism
Tract-based spatial statistics
Posterior superior temporal sulcus
Inferior fronto-occipital fasciculus
Issue Date: Dec-2014
Publisher: Elsevier Ltd.
Journal title: Journal of psychiatric research
Volume: 59
Start page: 117
End page: 124
Abstract: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with impairment of social communication and restricted and repetitive behaviors. Reduced fractional anisotropy (FA), a measure of white matter integrity, in the posterior superior temporal sulcus (pSTS) is related to ASD. However, there are several major fibers in pSTS, and it is unknown which of them is associated with ASD. We investigated FA in correlation with autistic traits assessed by autism spectrum quotient (AQ) in 91 healthy adults using tract-based spatial statistics (TBSS). Then, of the fibers in pSTS, we identified the one in which FA was linked to the AQ score using tractography. TBSS revealed that AQ was correlated with FA of white matter in several regions such as the frontal lobe, parietal lobe, occipital lobe and temporal lobe including pSTS. With further analysis using tractography, we confirmed that FA alteration in pSTS was located on the inferior fronto-occipital fasciculus (IFOF). IFOF has a critical role in processing socio-emotional information. Our findings suggest that of the fibers in pSTS, IFOF is a key fiber that links to autistic traits in healthy adults.
Rights: © 2014 Elsevier Ltd.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.jpsychires.2014.09.001
PubMed ID: 25266474
Appears in Collections:Journal Articles

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