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|j.jpsychires.2014.09.001.pdf||1.8 MB||Adobe PDF||View/Open|
|Title:||Fiber tract associated with autistic traits in healthy adults.|
Aso, Toshihiko https://orcid.org/0000-0003-4814-089X (unconfirmed)
|Author's alias:||廣瀬, 公人|
Tract-based spatial statistics
Posterior superior temporal sulcus
Inferior fronto-occipital fasciculus
|Journal title:||Journal of psychiatric research|
|Abstract:||Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with impairment of social communication and restricted and repetitive behaviors. Reduced fractional anisotropy (FA), a measure of white matter integrity, in the posterior superior temporal sulcus (pSTS) is related to ASD. However, there are several major fibers in pSTS, and it is unknown which of them is associated with ASD. We investigated FA in correlation with autistic traits assessed by autism spectrum quotient (AQ) in 91 healthy adults using tract-based spatial statistics (TBSS). Then, of the fibers in pSTS, we identified the one in which FA was linked to the AQ score using tractography. TBSS revealed that AQ was correlated with FA of white matter in several regions such as the frontal lobe, parietal lobe, occipital lobe and temporal lobe including pSTS. With further analysis using tractography, we confirmed that FA alteration in pSTS was located on the inferior fronto-occipital fasciculus (IFOF). IFOF has a critical role in processing socio-emotional information. Our findings suggest that of the fibers in pSTS, IFOF is a key fiber that links to autistic traits in healthy adults.|
|Rights:||© 2014 Elsevier Ltd.|
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|Appears in Collections:||Journal Articles |
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