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タイトル: Fgf16 is required for specification of GABAergic neurons and oligodendrocytes in the zebrafish forebrain.
著者: Miyake, Ayumi  kyouindb  KAKEN_id
Chitose, Tatsuya
Kamei, Eriko
Murakami, Atsuko
Nakayama, Yoshiaki
Konishi, Morichika
Itoh, Nobuyuki
著者名の別形: 三宅, 歩
発行日: 30-Oct-2014
出版者: Public Library of Science
誌名: PloS one
巻: 9
号: 10
論文番号: e110836
抄録: Fibroblast growth factor (Fgf) signaling plays crucial roles in various developmental processes including those in the brain. We examined the role of Fgf16 in the formation of the zebrafish brain. The knockdown of fgf16 decreased cell proliferation in the forebrain and midbrain. fgf16 was also essential for development of the ventral telencephalon and diencephalon, whereas fgf16 was not required for dorsoventral patterning in the midbrain. fgf16 was additionally required for the specification and differentiation of γ-aminobutyric acid (GABA)ergic interneurons and oligodendrocytes, but not for those of glutamatergic neurons in the forebrain. Cross talk between Fgf and Hedgehog (Hh) signaling was critical for the specification of GABAergic interneurons and oligodendrocytes. The expression of fgf16 in the forebrain was down-regulated by the inhibition of Hh and Fgf19 signaling, but not by that of Fgf3/Fgf8 signaling. The fgf16 morphant phenotype was similar to that of the fgf19 morphant and embryos blocked Hh signaling. The results of the present study indicate that Fgf16 signaling, which is regulated by the downstream pathways of Hh-Fgf19 in the forebrain, is involved in forebrain development.
著作権等: © 2014 Miyake et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/192765
DOI(出版社版): 10.1371/journal.pone.0110836
PubMed ID: 25357195
出現コレクション:学術雑誌掲載論文等

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