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j.radonc.2014.08.003.pdf | 352.79 kB | Adobe PDF | 見る/開く |
タイトル: | Evaluation of dynamic tumour tracking radiotherapy with real-time monitoring for lung tumours using a gimbal mounted linac. |
著者: | Matsuo, Yukinori https://orcid.org/0000-0002-4372-8259 (unconfirmed) Ueki, Nami Takayama, Kenji Nakamura, Mitsuhiro Miyabe, Yuki Ishihara, Yoshitomo Mukumoto, Nobutaka https://orcid.org/0000-0002-4569-3379 (unconfirmed) Yano, Shinsuke Tanabe, Hiroaki Kaneko, Shuji Mizowaki, Takashi https://orcid.org/0000-0002-8135-8746 (unconfirmed) Monzen, Hajime Sawada, Akira Kokubo, Masaki Hiraoka, Masahiro |
著者名の別形: | 松尾, 幸憲 |
キーワード: | Stereotactic body radiotherapy Lung cancer Dynamic tumour tracking Real-time monitoring Feasibility study |
発行日: | Sep-2014 |
出版者: | Elsevier Ireland Ltd. |
誌名: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology |
巻: | 112 |
号: | 3 |
開始ページ: | 360 |
終了ページ: | 364 |
抄録: | [Purpose]To evaluate feasibility and acute toxicities after dynamic tumour tracking (DTT) irradiation with real-time monitoring for lung tumours using a gimbal mounted linac. [Materials and methods]Spherical gold markers were placed around the tumour using a bronchoscope prior to treatment planning. Prescription dose at the isocentre was 56 Gy in 4 fractions for T2a lung cancer and metastatic tumour, and 48 Gy in 4 fractions for the others. Dose-volume metrics were compared between DTT and conventional static irradiation using in-house developed software. [Results]Of twenty-two patients enrolled, DTT radiotherapy was successfully performed for 16 patients, except 4 patients who coughed out the gold markers, one who showed spontaneous tumour regression, and one where the abdominal wall motion did not correlate with the tumour motion. Dose covering 95% volume of GTV was not different between the two techniques, while normal lung volume receiving 20 Gy or more was reduced by 20%. A mean treatment time per fraction was 36 min using DTT. With a median follow-up period of 13.2 months, no severe toxicity grade 3 or worse was observed. [Conclusions]DTT radiotherapy using a gimbal mounted linac was clinically feasible for lung treatment without any severe acute toxicity. |
著作権等: | © 2014 Elsevier Ireland Ltd. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/192774 |
DOI(出版社版): | 10.1016/j.radonc.2014.08.003 |
PubMed ID: | 25154320 |
出現コレクション: | 学術雑誌掲載論文等 |
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