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Title: Evaluation of dynamic tumour tracking radiotherapy with real-time monitoring for lung tumours using a gimbal mounted linac.
Authors: Matsuo, Yukinori  kyouindb  KAKEN_id  orcid (unconfirmed)
Ueki, Nami
Takayama, Kenji  kyouindb  KAKEN_id
Nakamura, Mitsuhiro  kyouindb  KAKEN_id
Miyabe, Yuki  kyouindb  KAKEN_id
Ishihara, Yoshitomo
Mukumoto, Nobutaka
Yano, Shinsuke
Tanabe, Hiroaki
Kaneko, Shuji
Mizowaki, Takashi  kyouindb  KAKEN_id  orcid (unconfirmed)
Monzen, Hajime
Sawada, Akira
Kokubo, Masaki
Hiraoka, Masahiro
Author's alias: 松尾, 幸憲
Keywords: Stereotactic body radiotherapy
Lung cancer
Dynamic tumour tracking
Real-time monitoring
Feasibility study
Issue Date: Sep-2014
Publisher: Elsevier Ireland Ltd.
Journal title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume: 112
Issue: 3
Start page: 360
End page: 364
Abstract: [Purpose]To evaluate feasibility and acute toxicities after dynamic tumour tracking (DTT) irradiation with real-time monitoring for lung tumours using a gimbal mounted linac. [Materials and methods]Spherical gold markers were placed around the tumour using a bronchoscope prior to treatment planning. Prescription dose at the isocentre was 56 Gy in 4 fractions for T2a lung cancer and metastatic tumour, and 48 Gy in 4 fractions for the others. Dose-volume metrics were compared between DTT and conventional static irradiation using in-house developed software. [Results]Of twenty-two patients enrolled, DTT radiotherapy was successfully performed for 16 patients, except 4 patients who coughed out the gold markers, one who showed spontaneous tumour regression, and one where the abdominal wall motion did not correlate with the tumour motion. Dose covering 95% volume of GTV was not different between the two techniques, while normal lung volume receiving 20 Gy or more was reduced by 20%. A mean treatment time per fraction was 36 min using DTT. With a median follow-up period of 13.2 months, no severe toxicity grade 3 or worse was observed. [Conclusions]DTT radiotherapy using a gimbal mounted linac was clinically feasible for lung treatment without any severe acute toxicity.
Rights: © 2014 Elsevier Ireland Ltd.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.radonc.2014.08.003
PubMed ID: 25154320
Appears in Collections:Journal Articles

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