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|Title:||Evaluation of dynamic tumour tracking radiotherapy with real-time monitoring for lung tumours using a gimbal mounted linac.|
|Authors:||Matsuo, Yukinori https://orcid.org/0000-0002-4372-8259 (unconfirmed)|
Mizowaki, Takashi https://orcid.org/0000-0002-8135-8746 (unconfirmed)
|Author's alias:||松尾, 幸憲|
|Keywords:||Stereotactic body radiotherapy|
Dynamic tumour tracking
|Publisher:||Elsevier Ireland Ltd.|
|Journal title:||Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology|
|Abstract:||[Purpose]To evaluate feasibility and acute toxicities after dynamic tumour tracking (DTT) irradiation with real-time monitoring for lung tumours using a gimbal mounted linac. [Materials and methods]Spherical gold markers were placed around the tumour using a bronchoscope prior to treatment planning. Prescription dose at the isocentre was 56 Gy in 4 fractions for T2a lung cancer and metastatic tumour, and 48 Gy in 4 fractions for the others. Dose-volume metrics were compared between DTT and conventional static irradiation using in-house developed software. [Results]Of twenty-two patients enrolled, DTT radiotherapy was successfully performed for 16 patients, except 4 patients who coughed out the gold markers, one who showed spontaneous tumour regression, and one where the abdominal wall motion did not correlate with the tumour motion. Dose covering 95% volume of GTV was not different between the two techniques, while normal lung volume receiving 20 Gy or more was reduced by 20%. A mean treatment time per fraction was 36 min using DTT. With a median follow-up period of 13.2 months, no severe toxicity grade 3 or worse was observed. [Conclusions]DTT radiotherapy using a gimbal mounted linac was clinically feasible for lung treatment without any severe acute toxicity.|
|Rights:||© 2014 Elsevier Ireland Ltd.|
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|Appears in Collections:||Journal Articles |
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