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1.JBO.19.9.090501.pdf1.21 MBAdobe PDF見る/開く
タイトル: Preclinical evaluation of a novel cyanine dye for tumor imaging with in vivo photoacoustic imaging.
著者: Temma, Takashi
Onoe, Satoru
Kanazaki, Kengo
Ono, Masahiro  kyouindb  KAKEN_id
Saji, Hideo
著者名の別形: 天滿, 敬
佐治, 英郎
発行日: Sep-2014
出版者: Society of Photo-Optical Instrumentation Engineers(SPIE.)
誌名: Journal of biomedical optics
巻: 19
号: 9
論文番号: 090501
抄録: Photoacoustic imaging (PA imaging or PAI) has shown great promise in the detection and monitoring of cancer. Although nanocarrier-based contrast agents have been studied for use in PAI, small molecule contrast agents are required due to their ease of preparation, costeffectiveness, and low toxicity. Here, we evaluated the usefulness of a novel cyanine dye IC7-1-Bu as a PAI contrast agent without conjugated targeting moieties for in vivo tumor imaging in a mice model. Basic PA characteristics of IC7-1-Bu were compared with indocyanine green (ICG), a Food and Drug Administration approved dye, in an aqueous solution. We evaluated the tumor accumulation profile of IC7-1-Bu and ICG by in vivo fluorescence imaging. In vivo PAI was then performed with a photoacoustic tomography system 24 and 48 h after intravenous injection of IC7-1-Bu into tumor bearing mice. IC7-1-Bu showed about a 2.3-fold higher PA signal in aqueous solution compared with that of ICG. Unlike ICG, IC7-1-Bu showed high tumor fluorescence after intravenous injection. In vivo PAI provided a tumor to background PA signal ratio of approximately 2.5 after intravenous injection of IC7-1-Bu. These results indicate that IC7-1-Bu is a promising PAI contrast agent for cancer imaging without conjugation of targeting moieties.
著作権等: Copyright 2014 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
URI: http://hdl.handle.net/2433/192898
DOI(出版社版): 10.1117/1.JBO.19.9.090501
PubMed ID: 25199057
出現コレクション:学術雑誌掲載論文等

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