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タイトル: | Rehabilitation program after mesenchymal stromal cell transplantation augmented by vascularized bone grafts for idiopathic osteonecrosis of the femoral head: a preliminary study. |
著者: | Aoyama, Tomoki Fujita, Yasuko Madoba, Katsuyuki Nankaku, Manabu Yamada, Minoru Tomita, Motoko Goto, Koji Ikeguchi, Ryosuke Kakinoki, Ryosuke Matsuda, Shuichi Nakamura, Takashi Toguchida, Junya |
著者名の別形: | 青山, 朋樹 後藤, 公志 池口, 良輔 松田, 秀一 戸口田, 淳也 |
キーワード: | Mesenchymal stromal cells Osteonecrosis Rehabilitation |
発行日: | Mar-2015 |
出版者: | Elsevier Inc. |
誌名: | Archives of physical medicine and rehabilitation |
巻: | 96 |
号: | 3 |
開始ページ: | 532 |
終了ページ: | 539 |
抄録: | [Objective]To determine the feasibility and safety of implementing a 12-week rehabilitation program after mesenchymal stromal cell (MSC) transplantation augmented by vascularized bone grafting for idiopathic osteonecrosis (ION) of the femoral head. [Design]A prospective case series. [Setting]University clinical research laboratory. [Participants]Participants (N=10) with ION who received MSC transplantation augmented by vascularized bone grafting. [Intervention]A 12-week exercise program, which included range-of-motion (ROM) exercises, muscle-strengthening exercises, and aerobic training. [Main Outcome Measures]Measures of ROM, muscle strength, Timed Up and Go test, and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) were collected before surgery and again at 6 and 12 months after surgery. [Results]All participants completed the 12-week program. External rotation ROM as well as extensor and abductor muscle strength significantly improved 6 months after treatment compared with that before treatment (P<.05). Significant improvements were also seen in physical function, role physical, and bodily pain subgroup scores of the SF-36 (P<.05). No serious adverse events occurred. [Conclusions]This study demonstrates the feasibility and safety of a multiplex rehabilitation program after MSC transplantation and provides support for further study on the benefits of rehabilitation programs in regenerative medicine. |
著作権等: | This is an open access article. © 2015 American Congress of Rehabilitation Medicine. |
URI: | http://hdl.handle.net/2433/196637 |
DOI(出版社版): | 10.1016/j.apmr.2014.09.040 |
PubMed ID: | 25450129 |
出現コレクション: | 学術雑誌掲載論文等 |
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