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Title: The Synthesis of Alkaloids Using Transition-Metal-Catalyzed Intramolecular Amination Reactions
Authors: Ohno, Hiroaki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-3246-4809 (unconfirmed)
Chiba, Hiroaki
Inuki, Shinsuke  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-7525-1280 (unconfirmed)
Oishi, Shinya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-2833-2539 (unconfirmed)
Fujii, Nobutaka
Author's alias: 大野, 浩章
Keywords: total synthesis
palladium
gold
alkaloids
atom economy
Issue Date: 13-Jan-2014
Publisher: Georg Thieme Verlag KG
Journal title: Synlett
Volume: 25
Issue: 02
Start page: 179
End page: 192
Abstract: Transition-metal-catalyzed reactions have the potential to provide significant improvements to the syntheses of complex target molecules. These reactions can be used to achieve a variety of different atom-economical transformations and cascade reactions and, therefore, provide access to synthetic strategies that would otherwise be unavailable using classical organic chemistry. To exemplify the utility of the latest transition-metal-catalyzed reactions for the construction of important target structures, we have been involved in the total synthesis of natural products bearing widely known chemical scaffolds. In this account, we report our recent studies on the use of a palladium-catalyzed cascade cyclization reaction and a gold(I)-catalyzed hydroamination reaction for the construction of the core structures of alkaloids, as well as their application to the total syntheses of lysergic acid, lysergol, isolysergol, and quinocarcin.
Rights: © Georg Thieme Verlag Stuttgart · New York
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/196783
DOI(Published Version): 10.1055/s-0033-1340165
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