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Title: Tandem duplications in the C-terminal domain of the mesotocin receptor exclusively identified among East Eurasian thrushes.
Authors: Abe, Hideaki
Nishiumi, Isao
Inoue-Murayama, Miho
Author's alias: 阿部, 秀明
村山, 美穂
Keywords: Mesotocin receptor
C-terminal domain
Tandem duplication
Polymorphism
Insertions and deletions
Turdus
Issue Date: 6-Nov-2013
Publisher: Springer US
Journal title: Journal of molecular evolution
Volume: 77
Issue: 5-6
Start page: 260
End page: 267
Abstract: Mesotocin is a neurohypophyseal hormone found in some non-mammalian vertebrates, including birds, reptiles, and amphibians. In this study, we identified and characterized 18-amino acid duplications in the C-terminal domain of the mesotocin receptor (MTR), specifically found in Turdus thrushes (Aves: Passeriforms: Turdidae). These duplicated elements are located in the distal part of the C-terminal tails of MTR and consist of amino acids that are highly conserved among major vertebrates. Intraspecific polymorphisms in a variable number of tandem duplications are commonly found in East Eurasian Turdus, but not in any other genus of Turdidae. Moreover, the genus Turdus can be further classified into 2 groups according to the presence or absence of a 3-amino acid deletion just adjacent to the putative palmitoylation site in the cytoplasmic C-terminal tail. The phylogeny presented here strongly supports the conspecific group of 4 East Eurasian thrushes (Turdus pallidus, T. chrysolaus, T. obscurus, and T. celaenops). Our findings, therefore, provide a new synapomorphy that can be used for phylogenetic assumptions and shed a light on the history of diversification within Eurasian Turdus clades.
Rights: The final publication is available at Springer via http://dx.doi.org/10.1007/s00239-013-9590-z
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/197381
DOI(Published Version): 10.1007/s00239-013-9590-z
PubMed ID: 24193891
Appears in Collections:Journal Articles

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