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Title: Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.
Authors: Mino, Takashi  kyouindb  KAKEN_id
Murakawa, Yasuhiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-5415-1352 (unconfirmed)
Fukao, Akira
Vandenbon, Alexis  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-2180-5732 (unconfirmed)
Wessels, Hans-Hermann
Ori, Daisuke
Uehata, Takuya
Tartey, Sarang
Akira, Shizuo
Suzuki, Yutaka
Vinuesa, Carola G
Ohler, Uwe
Standley, Daron M
Landthaler, Markus
Fujiwara, Toshinobu
Takeuchi, Osamu  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1260-6232 (unconfirmed)
Author's alias: 三野, 享史
竹内, 理
Issue Date: 21-May-2015
Publisher: Elsevier Inc.
Journal title: Cell
Volume: 161
Issue: 5
Start page: 1058
End page: 1073
Abstract: Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-related mRNAs and maintenance of immune homeostasis. However, their mechanistic relationship has yet to be clarified. Here, we show that, although Regnase-1 and Roquin regulate an overlapping set of mRNAs via a common stem-loop structure, they function in distinct subcellular locations: ribosome/endoplasmic reticulum and processing-body/stress granules, respectively. Moreover, Regnase-1 specifically cleaves and degrades translationally active mRNAs and requires the helicase activity of UPF1, similar to the decay mechanisms of nonsense mRNAs. In contrast, Roquin controls translationally inactive mRNAs, independent of UPF1. Defects in both Regnase-1 and Roquin lead to large increases in their target mRNAs, although Regnase-1 tends to control the early phase of inflammation when mRNAs are more actively translated. Our findings reveal that differential regulation of mRNAs by Regnase-1 and Roquin depends on their translation status and enables elaborate control of inflammation.
Description: 炎症がRNA分解により制御されるメカニズムを解明 -二つのブレーキが炎症を巧妙にストップする-. 京都大学プレスリリース. 2015-05-22.
Rights: © 2015 Elsevier Inc. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. NOTICE: this is the author's version of a work that was accepted for publication in Cell. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms. VOL.161, ISSUE.5, (2015) doi:10.1016/j.cell.2015.04.029.
許諾条件により本文は2016-05-21に公開.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/197955
DOI(Published Version): 10.1016/j.cell.2015.04.029
PubMed ID: 26000482
Related Link: http://www.kyoto-u.ac.jp/ja/research/research_results/2015/150512_2.html
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