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Title: Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals.
Authors: Kimura, Hiroyuki
Yagi, Yusuke
Ohneda, Noriyuki
Odajima, Hiro
Ono, Masahiro  kyouindb  KAKEN_id
Saji, Hideo
Author's alias: 木村, 寛之
佐治, 英郎
Keywords: resonant-type microwave reactor
positron emission tomography radiochemistry
Issue Date: 8-Aug-2014
Publisher: wiley
Journal title: Journal of labelled compounds & radiopharmaceuticals
Volume: 57
Issue: 12
Start page: 680
End page: 686
Abstract: Microwave technology has been successfully applied to enhance the effectiveness of radiolabeling reactions. The use of a microwave as a source of heat energy can allow chemical reactions to proceed over much shorter reaction times and in higher yields than they would do under conventional thermal conditions. A microwave reactor developed by Resonance Instrument Inc. (Model 520/521) and CEM (PETWave) has been used exclusively for the synthesis of radiolabeled agents for positron emission tomography by numerous groups throughout the world. In this study, we have developed a novel resonant-type microwave reactor powered by a solid-state device and confirmed that this system can focus microwave power on a small amount of reaction solution. Furthermore, we have demonstrated the rapid and facile radiosynthesis of 16α-[(18)F]fluoroestradiol, 4-[(18)F]fluoro-N-[2-(1-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinylbenzamide, and N-succinimidyl 4-[(18)F]fluorobenzoate using our newly developed microwave reactor.
Rights: This is the peer reviewed version of the following article: Kimura H., Yagi Y., Ohneda N., Odajima H., Ono M., and Saji H. (2014), Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals, J. Label Compd. Radiopharm, 57, pages 680–686, which has been published in final form at
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1002/jlcr.3232
PubMed ID: 25294422
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