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タイトル: Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals.
著者: Kimura, Hiroyuki
Yagi, Yusuke
Ohneda, Noriyuki
Odajima, Hiro
Ono, Masahiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-2497-039X (unconfirmed)
Saji, Hideo  kyouindb  KAKEN_id
著者名の別形: 木村, 寛之
佐治, 英郎
キーワード: resonant-type microwave reactor
positron emission tomography radiochemistry
[18F]-fluorination
[18F]FES
[18F]MPPF
[18F]SFB
発行日: 8-Aug-2014
出版者: Wiley
誌名: Journal of labelled compounds & radiopharmaceuticals
巻: 57
号: 12
開始ページ: 680
終了ページ: 686
抄録: Microwave technology has been successfully applied to enhance the effectiveness of radiolabeling reactions. The use of a microwave as a source of heat energy can allow chemical reactions to proceed over much shorter reaction times and in higher yields than they would do under conventional thermal conditions. A microwave reactor developed by Resonance Instrument Inc. (Model 520/521) and CEM (PETWave) has been used exclusively for the synthesis of radiolabeled agents for positron emission tomography by numerous groups throughout the world. In this study, we have developed a novel resonant-type microwave reactor powered by a solid-state device and confirmed that this system can focus microwave power on a small amount of reaction solution. Furthermore, we have demonstrated the rapid and facile radiosynthesis of 16α-[(18)F]fluoroestradiol, 4-[(18)F]fluoro-N-[2-(1-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinylbenzamide, and N-succinimidyl 4-[(18)F]fluorobenzoate using our newly developed microwave reactor.
著作権等: This is the peer reviewed version of the following article: Kimura H., Yagi Y., Ohneda N., Odajima H., Ono M., and Saji H. (2014), Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals, J. Label Compd. Radiopharm, 57, pages 680–686, which has been published in final form at http://dx.doi.org/10.1002/jlcr.3232.
許諾条件により本文ファイルは2015-08-08に公開.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/198616
DOI(出版社版): 10.1002/jlcr.3232
PubMed ID: 25294422
出現コレクション:学術雑誌掲載論文等

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