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タイトル: | Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals. |
著者: | Kimura, Hiroyuki Yagi, Yusuke Ohneda, Noriyuki Odajima, Hiro Ono, Masahiro https://orcid.org/0000-0002-2497-039X (unconfirmed) Saji, Hideo |
著者名の別形: | 木村, 寛之 佐治, 英郎 |
キーワード: | resonant-type microwave reactor positron emission tomography radiochemistry [18F]-fluorination [18F]FES [18F]MPPF [18F]SFB |
発行日: | 8-Aug-2014 |
出版者: | Wiley |
誌名: | Journal of labelled compounds & radiopharmaceuticals |
巻: | 57 |
号: | 12 |
開始ページ: | 680 |
終了ページ: | 686 |
抄録: | Microwave technology has been successfully applied to enhance the effectiveness of radiolabeling reactions. The use of a microwave as a source of heat energy can allow chemical reactions to proceed over much shorter reaction times and in higher yields than they would do under conventional thermal conditions. A microwave reactor developed by Resonance Instrument Inc. (Model 520/521) and CEM (PETWave) has been used exclusively for the synthesis of radiolabeled agents for positron emission tomography by numerous groups throughout the world. In this study, we have developed a novel resonant-type microwave reactor powered by a solid-state device and confirmed that this system can focus microwave power on a small amount of reaction solution. Furthermore, we have demonstrated the rapid and facile radiosynthesis of 16α-[(18)F]fluoroestradiol, 4-[(18)F]fluoro-N-[2-(1-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinylbenzamide, and N-succinimidyl 4-[(18)F]fluorobenzoate using our newly developed microwave reactor. |
著作権等: | This is the peer reviewed version of the following article: Kimura H., Yagi Y., Ohneda N., Odajima H., Ono M., and Saji H. (2014), Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals, J. Label Compd. Radiopharm, 57, pages 680–686, which has been published in final form at http://dx.doi.org/10.1002/jlcr.3232. 許諾条件により本文ファイルは2015-08-08に公開. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/198616 |
DOI(出版社版): | 10.1002/jlcr.3232 |
PubMed ID: | 25294422 |
出現コレクション: | 学術雑誌掲載論文等 |
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