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dc.contributor.authorKimura, Hiroyukien
dc.contributor.authorYagi, Yusukeen
dc.contributor.authorOhneda, Noriyukien
dc.contributor.authorOdajima, Hiroen
dc.contributor.authorOno, Masahiroen
dc.contributor.authorSaji, Hideoen
dc.contributor.alternative木村, 寛之ja
dc.contributor.alternative佐治, 英郎ja
dc.date.accessioned2015-07-02T04:35:27Z-
dc.date.available2015-07-02T04:35:27Z-
dc.date.issued2014-08-08-
dc.identifier.issn0362-4803-
dc.identifier.urihttp://hdl.handle.net/2433/198616-
dc.description.abstractMicrowave technology has been successfully applied to enhance the effectiveness of radiolabeling reactions. The use of a microwave as a source of heat energy can allow chemical reactions to proceed over much shorter reaction times and in higher yields than they would do under conventional thermal conditions. A microwave reactor developed by Resonance Instrument Inc. (Model 520/521) and CEM (PETWave) has been used exclusively for the synthesis of radiolabeled agents for positron emission tomography by numerous groups throughout the world. In this study, we have developed a novel resonant-type microwave reactor powered by a solid-state device and confirmed that this system can focus microwave power on a small amount of reaction solution. Furthermore, we have demonstrated the rapid and facile radiosynthesis of 16α-[(18)F]fluoroestradiol, 4-[(18)F]fluoro-N-[2-(1-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinylbenzamide, and N-succinimidyl 4-[(18)F]fluorobenzoate using our newly developed microwave reactor.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWileyen
dc.rightsThis is the peer reviewed version of the following article: Kimura H., Yagi Y., Ohneda N., Odajima H., Ono M., and Saji H. (2014), Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals, J. Label Compd. Radiopharm, 57, pages 680–686, which has been published in final form at http://dx.doi.org/10.1002/jlcr.3232.en
dc.rights許諾条件により本文ファイルは2015-08-08に公開.ja
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.rightsThis is not the published version. Please cite only the published version.en
dc.subjectresonant-type microwave reactoren
dc.subjectpositron emission tomography radiochemistryen
dc.subject[18F]-fluorinationen
dc.subject[18F]FESen
dc.subject[18F]MPPFen
dc.subject[18F]SFBen
dc.titleDevelopment of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals.en
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.ncidAA00701124-
dc.identifier.jtitleJournal of labelled compounds & radiopharmaceuticalsen
dc.identifier.volume57-
dc.identifier.issue12-
dc.identifier.spage680-
dc.identifier.epage686-
dc.relation.doi10.1002/jlcr.3232-
dc.textversionauthor-
dc.startdate.bitstreamsavailable2015-08-08-
dc.identifier.pmid25294422-
dcterms.accessRightsopen access-
dc.identifier.pissn0362-4803-
dc.identifier.eissn1099-1344-
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