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タイトル: | Human T-cell leukemia virus type 1 and Foxp3 expression: viral strategy in vivo. |
著者: | Miyazato, Paola Matsuoka, Masao |
著者名の別形: | 松岡, 雅雄 |
キーワード: | HBZ HTLV-1 Treg cells |
発行日: | 2-May-2014 |
出版者: | Oxford University Press |
誌名: | International immunology |
巻: | 26 |
号: | 8 |
開始ページ: | 419 |
終了ページ: | 425 |
抄録: | Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of adult T-cell leukemia (ATL) and inflammatory diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis, uveitis and infective dermatitis. However, it remains to be elucidated how HTLV-1 induces both neoplastic and inflammatory diseases. A critical component in the Treg-cell machinery is the transcription factor Forkhead box P3 (Foxp3), which is expressed in ~5% of CD4(+) T cells of healthy individuals. Foxp3 is expressed in around 80% of ATL cases. Recent studies point to the capacity of Treg cells to convert to other cell types, even to those with an inflammatory phenotype. These characteristics might indicate that Treg cells might be playing a critical role in HTLV-1 infection, either by being targeted by the virus or by regulating and modulating the immune response. In this review, we will discuss the interplay between Foxp3 expression and HTLV-1, focusing on important viral proteins that might help the virus to trigger the development of such diverse pathologies. |
著作権等: | This is a pre-copyedited, author-produced PDF of an article accepted for publication in [International immunology] following peer review. The version of record [Paola Miyazato , Masao Matsuoka. Human T-cell leukemia virus type 1 and Foxp3 expression: viral strategy in vivo. (2014) 26 (8): 419-425.] is available online at: http://dx.doi.org/10.1093/intimm/dxu048. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/198718 |
DOI(出版社版): | 10.1093/intimm/dxu048 |
PubMed ID: | 24792037 |
出現コレクション: | 学術雑誌掲載論文等 |
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