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Title: Regulatory expression of components in the BMP pathway in white adipose tissues of cattle
Authors: Qiao, Yuhang
Yamada, Tomoya
Kanamori, Yohei
Kida, Ryosuke
Shigematsu, Mei
Fujimoto, Yusuke
Tomonaga, Shozo  kyouindb  KAKEN_id  orcid (unconfirmed)
Matsui, Tohru
Funaba, Masayuki  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 舟場, 正幸
Keywords: BMP
Brown adipocyte
Beige adipocyte
Issue Date: Apr-2015
Publisher: Elsevier B.V.
Journal title: Livestock Science
Volume: 174
Start page: 144
End page: 149
Abstract: The BMP pathway positively regulates murine brown adipogenesis. We herein examined the mRNA levels of BMPs and activin βB as well as receptors for the BMP pathway in the adipose tissues of cattle fed diets with a differential ratio of concentrate to roughage or a vitamin A-deficient diet. The expression of activin βB was significantly increased in the subcutaneous fat depot of animals fed the concentrate diet, while the vitamin A-deficient diet significantly increased the expression of BMP4 in the mesenteric fat depot. The expression of receptors for the BMP pathway, ALK2, ALK3, ActRIIA, and BMPR2, showed a similar pattern to that of BMP4 and activin βB in response to the dietary treatments. The results of the present study demonstrated that diet modulated the expression of components of the BMP pathway and may be responsible for the regulatory expression of brown/beige adipocyte-related genes in the adipose tissues of cattle.
Rights: © 2015 Elsevier B.V. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International NOTICE: this is the author's version of a work that was accepted for publication in [Livestock Science]. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in [Livestock Science, Volume 174, Pages 144–149], doi:10.1016/j.livsci.2015.02.008.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.livsci.2015.02.008
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