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dc.contributor.author | Nakatsuji, Hirotaka | en |
dc.contributor.author | Numata, Tomohiro | en |
dc.contributor.author | Morone, Nobuhiro | en |
dc.contributor.author | Kaneko, Shuji | en |
dc.contributor.author | Mori, Yasuo | en |
dc.contributor.author | Imahori, Hiroshi | en |
dc.contributor.author | Murakami, Tatsuya | en |
dc.contributor.alternative | 村上, 達也 | ja |
dc.date.accessioned | 2015-08-17T02:45:55Z | - |
dc.date.available | 2015-08-17T02:45:55Z | - |
dc.date.issued | 2015-08-06 | - |
dc.identifier.issn | 1521-3773 | - |
dc.identifier.uri | http://hdl.handle.net/2433/199567 | - |
dc.description | 光を使って神経細胞の「痛み」感知を制御する手法を開発 -新しい鎮痛療法の可能性-. 京都大学プレスリリース. 2015-08-14. | ja |
dc.description.abstract | Controlling cell functions using external photoresponsive nanomaterials has enormous potential for the development of cell-engineering technologies and intractable disease therapies, but the former currently requires genetic modification of the target cells. We present a method using plasma-membrane-targeted gold nanorods (pm-AuNRs) prepared with a cationic protein/lipid complex to activate a thermosensitive cation channel, TRPV1, in intact neuronal cells. Highly localized photothermal heat generation mediated by the pm-AuNRs induced Ca(2+) influx solely by TRPV1 activation. In contrast, the use of previously reported cationic AuNRs that are coated with a conventional synthetic polymer also led to photoinduced Ca(2+) influx, but this influx resulted from membrane damage. Our method provides an optogenetic platform without the need for prior genetic engineering of the target cells and might be useful for novel TRPV1-targeted phototherapeutic approaches. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | en |
dc.rights | This is the peer reviewed version of the following article: Nakatsuji, H., Numata, T., Morone, N., Kaneko, S., Mori, Y., Imahori, H. and Murakami, T. (2015), Thermosensitive Ion Channel Activation in Single Neuronal Cells by Using Surface-Engineered Plasmonic Nanoparticles. Angew. Chem. Int. Ed., 54: 11725–11729, which has been published in final form at http://dx.doi.org/10.1002/anie.201505534. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en |
dc.rights | The full-text file will be made open to the public on 06 August 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | cell engineering | en |
dc.subject | ion channels | en |
dc.subject | nanoparticles | en |
dc.subject | photothermal effects | en |
dc.subject | surface chemistry | en |
dc.title | Thermosensitive Ion Channel Activation in Single Neuronal Cells by Using Surface-Engineered Plasmonic Nanoparticles. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Angewandte Chemie | en |
dc.identifier.volume | 54 | - |
dc.identifier.issue | 40 | - |
dc.identifier.spage | 11725 | - |
dc.identifier.epage | 11729 | - |
dc.relation.doi | 10.1002/anie.201505534 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2016-08-06 | - |
dc.identifier.pmid | 26249533 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2015-08-14-0 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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