Downloads: 159

Files in This Item:
File Description SizeFormat 
bcr-2013-203485.pdf173.82 kBAdobe PDFView/Open
Title: Voriconazole-induced periostitis in a patient with overlap syndromes.
Authors: Hirota, Keisho
Yasoda, Akihiro  kyouindb  KAKEN_id
Fujii, Toshihito  kyouindb  KAKEN_id
Inagaki, Nobuya  kyouindb  KAKEN_id
Author's alias: 八十田, 明宏
Issue Date: 5-Mar-2014
Publisher: BMJ Publishing Group
Journal title: BMJ case reports
Volume: 2014
Abstract: A 52-year-old woman with overlap syndrome and interstitial pneumonia underwent immunosuppressive therapy and she was suspected to suffer from pulmonary aspergillosis. Oral voriconazole was initiated, and a rapid elevation of alkaline phosphatase (ALP) occurred after 4 weeks. After 2 months, the patient presented diffuse pain in bilateral skeletal regions, and bone scintigraphy revealed bilateral multiple areas of increased radiotracer uptake. We suspected the skeletal involvement as voriconazole-induced periostitis. Actually, the plasma fluoride level was increased. Voriconazole was replaced with itraconazole, and after 3 weeks, the patient stopped complaining of bone pain concomitant with the decrease in ALP. Voriconazole-induced periostitis is a rare condition but had previously been reported in solid organ or patients with bone marrow transplant who received a long-term voriconazole therapy. Our present case is distinctive of previous ones, because it occurred in a patient with connective tissue disease which had its rapid progression.
Rights: This article has been accepted for publication in BMJ Case Reports following peer review. The definitive copyedited, typeset version [Keisho Hirota, Akihiro Yasoda, Toshihito Fujii, Nobuya Inagaki. Voriconazole-induced periostitis in a patient with overlap syndromes. BMJ Case Reports 2014; doi:10.1136/bcr-2013-203485] is available online at: http://casereports.bmj.com/content/2014/bcr-2013-203485.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/199586
DOI(Published Version): 10.1136/bcr-2013-203485
PubMed ID: 24599432
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.