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タイトル: | Facilitated Transport of Ions and Glucose by Amphotericin B Across Lipid Bilayers in the Presence or Absence of Cholesterol |
著者: | Kagohashi, Hiroki Shirai, Osamu Kubota, Shintaro Kitazumi, Yuki https://orcid.org/0000-0001-6171-6457 (unconfirmed) Kano, Kenji |
著者名の別形: | 白井, 理 |
キーワード: | Amphotericin B Bilayer lipid membrane Ion transport Liposome Glucose Cholesterol |
発行日: | Mar-2014 |
誌名: | Electroanalysis |
巻: | 26 |
号: | 3 |
開始ページ: | 625 |
終了ページ: | 631 |
抄録: | The transport of ions and glucose across bilayer lipid membranes (BLM) facilitated by amphotericin B (AmB) is studied by use of planar BLMs and liposomal membranes. The transport characteristics change with time in the presence of cholesterol, while it is independent of time in the absence of cholesterol. The carrier-type transport is observed immediately after the addition of AmB. In the presence of cholesterol, AmB forms a 1 : 1 complex with cholesterol and the channel is formed by aggregation of AmB-cholesterol complexes. It is concluded that the number of the channels increases with time and that the carrier-type transport decreases instead. |
著作権等: | This is the peer reviewed version of the following article: Kagohashi, H., Shirai, O., Kubota, S., Kitazumi, Y. and Kano, K. (2014), Facilitated Transport of Ions and Glucose by Amphotericin B Across Lipid Bilayers in the Presence or Absence of Cholesterol. Electroanalysis, 26: 625–631, which has been published in final form at http://dx.doi.org/10.1002/elan.201300555. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/199597 |
DOI(出版社版): | 10.1002/elan.201300555 |
出現コレクション: | 学術雑誌掲載論文等 |
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