ダウンロード数: 215
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
s00705-013-1960-8.pdf | 364.29 kB | Adobe PDF | 見る/開く |
タイトル: | Sequence analysis of the CXCR4 gene derived from cells surviving feline lentivirus infection. |
著者: | Tochikura, Tadafumi S Morimoto, Kinjiro |
著者名の別形: | 栃倉, 匡文 |
キーワード: | Feline immunodeficiency virus 3201 3201-S CXCR4 Sequence analysis |
発行日: | Jun-2014 |
出版者: | Springer |
誌名: | Archives of virology |
巻: | 159 |
号: | 6 |
開始ページ: | 1511 |
終了ページ: | 1513 |
抄録: | The feline 3201-S cell line was established from cells that survived productive infection with feline immunodeficiency virus (FIV). We have recently shown that 3201-S cells are free of FIV DNA and are refractory to FIV reinfection. In addition, while the cells express CXCR4, a co-receptor for FIV infection, they are unresponsive to the CXCR4 ligand. In the present study, we show that 3201-S cells encode distinct mutations in the CXCR4 gene. It appears that 3201 cells are heterogeneous, consisting of phenotypically diverse mixed populations resulting from genetic mutations, suggesting that this defect can render the CXCR4 receptor expressed in 3201-S cells biologically dysfunctional. |
著作権等: | The final publication is available at Springer via http://dx.doi.org/10.1007/s00705-013-1960-8. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/199622 |
DOI(出版社版): | 10.1007/s00705-013-1960-8 |
PubMed ID: | 24370967 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。