ダウンロード数: 246
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
asia.201402331.pdf | 4.25 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Taylor, Rhys Dylan | en |
dc.contributor.author | Kawamoto, Yusuke | en |
dc.contributor.author | Hashiya, Kaori | en |
dc.contributor.author | Bando, Toshikazu | en |
dc.contributor.author | Sugiyama, Hiroshi | en |
dc.contributor.alternative | 板東, 俊和 | ja |
dc.date.accessioned | 2015-08-27T05:32:24Z | - |
dc.date.available | 2015-08-27T05:32:24Z | - |
dc.date.issued | 2014-06-18 | - |
dc.identifier.issn | 1861-4728 | - |
dc.identifier.uri | http://hdl.handle.net/2433/199657 | - |
dc.description.abstract | Tandem N-methylpyrrole-N-methylimidazole (Py-Im) polyamides with good sequence-specific DNA-alkylating activities have been designed and synthesized. Three alkylating tandem Py-Im polyamides with different linkers, which each contained the same moiety for the recognition of a 10 bp DNA sequence, were evaluated for their reactivity and selectivity by DNA alkylation, using high-resolution denaturing gel electrophoresis. All three conjugates displayed high reactivities for the target sequence. In particular, polyamide 1, which contained a β-alanine linker, displayed the most-selective sequence-specific alkylation towards the target 10 bp DNA sequence. The tandem Py-Im polyamide conjugates displayed greater sequence-specific DNA alkylation than conventional hairpin Py-Im polyamide conjugates (4 and 5). For further research, the design of tandem Py-Im polyamide conjugates could play an important role in targeting specific gene sequences. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | wiley | en |
dc.rights | This is the peer reviewed version of the following article: Taylor, R. D., Kawamoto, Y., Hashiya, K., Bando, T. and Sugiyama, H. (2014), Sequence-Specific DNA Alkylation by Tandem Py–Im Polyamide Conjugates. Chem. Asian J., 9: 2527–2533, which has been published in final form at http://dx.doi.org/10.1002/asia.201402331. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | alkylation | en |
dc.subject | amides | en |
dc.subject | conjugates | en |
dc.subject | DNA | en |
dc.subject | polymers | en |
dc.subject.mesh | Alkylation | en |
dc.subject.mesh | Base Sequence | en |
dc.subject.mesh | DNA/chemistry | en |
dc.subject.mesh | DNA/genetics | en |
dc.subject.mesh | Imidazoles/chemistry | en |
dc.subject.mesh | Models, Molecular | en |
dc.subject.mesh | Molecular Structure | en |
dc.subject.mesh | Nylons/chemistry | en |
dc.subject.mesh | Pyrroles/chemistry | en |
dc.title | Sequence-specific DNA alkylation by tandem Py-Im polyamide conjugates. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Chemistry -- an Asian journal | en |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 2527 | - |
dc.identifier.epage | 2533 | - |
dc.relation.doi | 10.1002/asia.201402331 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2015-06-18 | - |
dc.identifier.pmid | 24942204 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。