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タイトル: Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.
著者: Tartey, Sarang
Matsushita, Kazufumi
Vandenbon, Alexis  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-2180-5732 (unconfirmed)
Ori, Daisuke
Imamura, Tomoko
Mino, Takashi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9562-008X (unconfirmed)
Standley, Daron M
Hoffmann, Jules A
Reichhart, Jean-Marc
Akira, Shizuo
Takeuchi, Osamu  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1260-6232 (unconfirmed)
著者名の別形: 竹内, 理
発行日: 16-Oct-2014
出版者: EMBO press
誌名: The EMBO Journal
巻: 33
号: 20
開始ページ: 2332
終了ページ: 2348
抄録: Transcription of inflammatory genes in innate immune cells is coordinately regulated by transcription factors, including NF-κB, and chromatin modifiers. However, it remains unclear how microbial sensing initiates chromatin remodeling. Here, we show that Akirin2, an evolutionarily conserved nuclear protein, bridges NF-κB and the chromatin remodeling SWI/SNF complex by interacting with BRG1-Associated Factor 60 (BAF60) proteins as well as IκB-ζ, which forms a complex with the NF-κB p50 subunit. These interactions are essential for Toll-like receptor-, RIG-I-, and Listeria-mediated expression of proinflammatory genes including Il6 and Il12b in macrophages. Consistently, effective clearance of Listeria infection required Akirin2. Furthermore, Akirin2 and IκB-ζ recruitment to the Il6 promoter depend upon the presence of IκB-ζ and Akirin2, respectively, for regulation of chromatin remodeling. BAF60 proteins were also essential for the induction of Il6 in response to LPS stimulation. Collectively, the IκB-ζ-Akirin2-BAF60 complex physically links the NF-κB and SWI/SNF complexes in innate immune cell activation. By recruiting SWI/SNF chromatin remodellers to IκB-ζ, transcriptional coactivator for NF-κB, the conserved nuclear protein Akirin2 stimulates pro-inflammatory gene promoters in mouse macrophages during innate immune responses to viral or bacterial infection.
著作権等: © 2014 The Authors.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/199669
DOI(出版社版): 10.15252/embj.201488447
PubMed ID: 25107474
出現コレクション:学術雑誌掲載論文等

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