ダウンロード数: 300
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
adsc.201400078.pdf | 172.3 kB | Adobe PDF | 見る/開く |
タイトル: | Palladium(0)-Catalyzed Carbon[BOND]Hydrogen Bond Functionalization for the Synthesis of Indoloquinazolinones |
著者: | Tsukano, Chihiro https://orcid.org/0000-0002-9361-0857 (unconfirmed) Okuno, Masataka Nishiguchi, Hiromi Takemoto, Yoshiji https://orcid.org/0000-0003-1375-3821 (unconfirmed) |
著者名の別形: | 塚野, 千尋 竹本, 佳司 |
キーワード: | C[BOND]H functionalization cyclization indoloquinazolinone palladium regioselectivity substituent effects |
発行日: | 5-May-2014 |
出版者: | Wiley |
誌名: | Advanced Synthesis & Catalysis |
巻: | 356 |
号: | 7 |
開始ページ: | 1533 |
終了ページ: | 1538 |
抄録: | The indoloquinazolinone ring system has attracted considerable attention as a pharmacophore, because it shows various biological activities. The reported synthetic methods for the compound are simple and direct, but are not effective for the direct synthesis of indoloquinazolinone with a methylene group at the C-6 position. A palladium(0)-catalyzed cyclization of chloroquinazolinone via C H functionalization was developed for a concise synthesis of indoloquinazolinone derivatives. The presence of a substituent at the C-6 position is important for obtaining the product in good yield. The conformation of the reaction intermediate, in particular the N C Pd bond angle, is important for the regioselectivity of the reaction. |
著作権等: | This is the peer reviewed version of the following article: Tsukano, C., Okuno, M., Nishiguchi, H. and Takemoto, Y. (2014), Palladium(0)-Catalyzed Carbon[BOND]Hydrogen Bond Functionalization for the Synthesis of Indoloquinazolinones. Adv. Synth. Catal., 356: 1533–1538, which has been published in final form at http://dx.doi.org/10.1002/adsc.201400078. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/199889 |
DOI(出版社版): | 10.1002/adsc.201400078 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。