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タイトル: Palladium(0)-Catalyzed Carbon[BOND]Hydrogen Bond Functionalization for the Synthesis of Indoloquinazolinones
著者: Tsukano, Chihiro  kyouindb  KAKEN_id
Okuno, Masataka
Nishiguchi, Hiromi
Takemoto, Yoshiji  kyouindb  KAKEN_id
著者名の別形: 塚野, 千尋
竹本, 佳司
キーワード: C[BOND]H functionalization
cyclization
indoloquinazolinone
palladium
regioselectivity
substituent effects
発行日: 5-May-2014
出版者: wiley
誌名: Advanced Synthesis & Catalysis
巻: 356
号: 7
開始ページ: 1533
終了ページ: 1538
抄録: The indoloquinazolinone ring system has attracted considerable attention as a pharmacophore, because it shows various biological activities. The reported synthetic methods for the compound are simple and direct, but are not effective for the direct synthesis of indoloquinazolinone with a methylene group at the C-6 position. A palladium(0)-catalyzed cyclization of chloroquinazolinone via C H functionalization was developed for a concise synthesis of indoloquinazolinone derivatives. The presence of a substituent at the C-6 position is important for obtaining the product in good yield. The conformation of the reaction intermediate, in particular the N C Pd bond angle, is important for the regioselectivity of the reaction.
著作権等: This is the peer reviewed version of the following article: Tsukano, C., Okuno, M., Nishiguchi, H. and Takemoto, Y. (2014), Palladium(0)-Catalyzed Carbon[BOND]Hydrogen Bond Functionalization for the Synthesis of Indoloquinazolinones. Adv. Synth. Catal., 356: 1533–1538, which has been published in final form at http://dx.doi.org/10.1002/adsc.201400078. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/199889
DOI(出版社版): 10.1002/adsc.201400078
出現コレクション:学術雑誌掲載論文等

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