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|Title:||Sonication-induced formation of size-controlled self-assemblies of amphiphilic Janus-type polymers as optical tumor-imaging agents.|
|Authors:||Miki, Koji https://orcid.org/0000-0002-4670-2302 (unconfirmed)|
Harada, Hiroshi https://orcid.org/0000-0001-7507-3173 (unconfirmed)
|Author's alias:||三木, 康嗣|
|Abstract:||In this study, amphiphilic Janus-type polymers were synthesized via ring-opening metathesis polymerization (ROMP), multiple vicinal diol formation, and grafting of poly(ethylene glycol) monomethyl ether (mPEG). These amphiphilic polymers formed self-assemblies, which were a mixture of micelles and multimicellar aggregates, in water. By choosing suitable Janus-type polymers and irradiating an aqueous solution of polymers using a sonicator, either small micelles or large multimicellar aggregates were obtained selectively. Hydrophobic substituents controlled the aggregation-disaggregation behavior, leading to the formation of metastable self-assemblies by sonication. The formation of self-assemblies with a uniform size was affected by ultrasonic frequency, rather than power. In vivo optical tumor imaging revealed that the large-size multimicellar aggregates persisting for a long time in blood circulation slowly accumulated in tumor tissues. In contrast, the tumor site was rapidly, clearly visualized using the small-size micelles.|
|Rights:||This is the peer reviewed version of the following article: Miki, K., Hashimoto, H., Inoue, T., Matsuoka, H., Harada, H., Hiraoka, M. and Ohe, K. (2014), Sonication-Induced Formation of Size-Controlled Self-Assemblies of Amphiphilic Janus-Type Polymers as Optical Tumor-Imaging Agents. Small, 10: 3119–3130, which has been published in final form at http://dx.doi.org/10.1002/smll.201400358. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.|
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
|Appears in Collections:||Journal Articles|
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