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Title: Sonication-induced formation of size-controlled self-assemblies of amphiphilic Janus-type polymers as optical tumor-imaging agents.
Authors: Miki, Koji  kyouindb  KAKEN_id  orcid (unconfirmed)
Hashimoto, Hiroki
Inoue, Tatsuhiro
Matsuoka, Hideki  kyouindb  KAKEN_id
Harada, Hiroshi  kyouindb  KAKEN_id  orcid (unconfirmed)
Hiraoka, Masahiro
Ohe, Kouichi
Author's alias: 三木, 康嗣
Keywords: janus-type polymer
tumor imaging
Issue Date: 14-Apr-2014
Publisher: wiley
Journal title: Small
Volume: 10
Issue: 15
Start page: 3119
End page: 3130
Abstract: In this study, amphiphilic Janus-type polymers were synthesized via ring-opening metathesis polymerization (ROMP), multiple vicinal diol formation, and grafting of poly(ethylene glycol) monomethyl ether (mPEG). These amphiphilic polymers formed self-assemblies, which were a mixture of micelles and multimicellar aggregates, in water. By choosing suitable Janus-type polymers and irradiating an aqueous solution of polymers using a sonicator, either small micelles or large multimicellar aggregates were obtained selectively. Hydrophobic substituents controlled the aggregation-disaggregation behavior, leading to the formation of metastable self-assemblies by sonication. The formation of self-assemblies with a uniform size was affected by ultrasonic frequency, rather than power. In vivo optical tumor imaging revealed that the large-size multimicellar aggregates persisting for a long time in blood circulation slowly accumulated in tumor tissues. In contrast, the tumor site was rapidly, clearly visualized using the small-size micelles.
Rights: This is the peer reviewed version of the following article: Miki, K., Hashimoto, H., Inoue, T., Matsuoka, H., Harada, H., Hiraoka, M. and Ohe, K. (2014), Sonication-Induced Formation of Size-Controlled Self-Assemblies of Amphiphilic Janus-Type Polymers as Optical Tumor-Imaging Agents. Small, 10: 3119–3130, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1002/smll.201400358
PubMed ID: 24729486
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