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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| anie.201411954.pdf | 293.51 kB | Adobe PDF | 見る/開く |
| タイトル: | Total synthesis of (-)-caprazamycin A. |
| 著者: | Nakamura, Hugh Tsukano, Chihiro    https://orcid.org/0000-0002-9361-0857 (unconfirmed)Yasui, Motohiro Yokouchi, Shinsuke Igarashi, Masayuki Takemoto, Yoshiji https://orcid.org/0000-0003-1375-3821 (unconfirmed) |
| 著者名の別形: | 塚野, 千尋 竹本, 佳司 |
| キーワード: | aldol reaction antibiotics natural products organocatalysis total synthesis |
| 発行日: | 22-Jan-2015 |
| 出版者: | Wiley |
| 誌名: | Angewandte Chemie |
| 巻: | 54 |
| 号: | 10 |
| 開始ページ: | 3136 |
| 終了ページ: | 3139 |
| 抄録: | Caprazamycin A has significant antibacterial activity against Mycobacterium tuberculosis (TB). The first total synthesis is herein reported and features a) the scalable preparation of the syn-β-hydroxy amino acid with a thiourea-catalyzed diastereoselective aldol reaction, b) construction of a diazepanone with an unstable fatty-acid side chain, and c) global deprotection with hydrogenation. This report provides a route for the synthesis of related liponucleoside antibiotics with fatty-acid side chains. |
| 著作権等: | This is the peer reviewed version of the following article: Nakamura, H., Tsukano, C., Yasui, M., Yokouchi, S., Igarashi, M. and Takemoto, Y. (2015), Total Synthesis of (−)-Caprazamycin A. Angew. Chem. Int. Ed., 54: 3136–3139, which has been published in final form at http://dx.doi.org/10.1002/anie.201411954. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. The full-text file will be made open to the public on 22 JAN 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/200201 |
| DOI(出版社版): | 10.1002/anie.201411954 |
| PubMed ID: | 25613457 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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