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Title: Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation.
Authors: Kasubuchi, Mayu
Hasegawa, Sae
Hiramatsu, Takero
Ichimura, Atsuhiko  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-0366-5211 (unconfirmed)
Kimura, Ikuo
Author's alias: 木村, 郁夫
Keywords: SCFA
gut microbiota
energy metabolism
GPR41
GPR43
Issue Date: 14-Apr-2015
Publisher: MDPI
Journal title: Nutrients
Volume: 7
Issue: 4
Start page: 2839
End page: 2849
Abstract: During feeding, the gut microbiota contributes to the host energy acquisition and metabolic regulation thereby influencing the development of metabolic disorders such as obesity and diabetes. Short-chain fatty acids (SCFAs) such as acetate, butyrate, and propionate, which are produced by gut microbial fermentation of dietary fiber, are recognized as essential host energy sources and act as signal transduction molecules via G-protein coupled receptors (FFAR2, FFAR3, OLFR78, GPR109A) and as epigenetic regulators of gene expression by the inhibition of histone deacetylase (HDAC). Recent evidence suggests that dietary fiber and the gut microbial-derived SCFAs exert multiple beneficial effects on the host energy metabolism not only by improving the intestinal environment, but also by directly affecting various host peripheral tissues. In this review, we summarize the roles of gut microbial SCFAs in the host energy regulation and present an overview of the current understanding of its physiological functions.
Rights: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/200693
DOI(Published Version): 10.3390/nu7042839
PubMed ID: 25875123
Appears in Collections:Journal Articles

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