|Title:||Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold.|
Shimura, Kazuya https://orcid.org/0000-0001-7819-5184 (unconfirmed)
Ohno, Hiroaki https://orcid.org/0000-0002-3246-4809 (unconfirmed)
Oishi, Shinya https://orcid.org/0000-0002-2833-2539 (unconfirmed)
|Author's alias:||大石, 真也|
|Journal title:||Bioorganic & medicinal chemistry|
|Abstract:||3, 4-Dihydro-2H-benzo[4, 5]isothiazolo[2, 3-a]pyrimidine is a newly identified antiviral agent against human immunodeficiency virus type 1 (HIV-1) infection, derived from 3, 4-dihydro-2H, 6H-pyrimido[1, 2-c][1, 3]benzothiazin-6-imine (PD 404182). The introduction of the hydrophobic 8-aryl substituent on the benzene substructure improved its anti-HIV activity, resulting in the identification of 6-fold more potent analogs. In addition, it was demonstrated that these isothiazolopyrimidine derivatives exert anti-HIV effects at an early stage of viral infection.|
|Rights:||© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/|
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|Appears in Collections:||Journal Articles|
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