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タイトル: Genetic pathways for differentiation of the peripheral nervous system in ascidians.
著者: Waki, Kana
Imai, Kaoru S
Satou, Yutaka  kyouindb  KAKEN_id
著者名の別形: 脇, 華菜
佐藤, ゆたか
キーワード: Biological sciences
Developmental biology
Evolution
発行日: 30-Oct-2015
出版者: Nature Publishing Group
誌名: Nature communications
巻: 6
論文番号: 8719
抄録: Ascidians belong to tunicates, the sister group of vertebrates. Peripheral nervous systems (PNSs) including epidermal sensory neurons (ESNs) in the trunk and dorsal tail regions of ascidian larvae are derived from cells adjacent to the neural plate, as in vertebrates. On the other hand, peripheral ESNs in the ventral tail region are derived from the ventral ectoderm under the control of BMP signalling, reminiscent of sensory neurons of amphioxus and protostomes. In this study, we show that two distinct mechanisms activate a common gene circuit consisting of Msx, Ascl.b, Tox, Delta.b and Pou4 in the dorsal and ventral regions to differentiate ESNs. Our results suggest that ventral ESNs of the ascidian larva are not directly homologous to vertebrate PNSs. The dorsal ESNs might have arisen via co-option of the original PNS gene circuit to the neural plate border in an ancestral chordate.
記述: 脊椎動物の感覚神経の進化的起源 -脊椎動物のもつ多様な感覚神経は進化の過程で再獲得された-. 京都大学プレスリリース. 2015-10-30.
著作権等: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
URI: http://hdl.handle.net/2433/200841
DOI(出版社版): 10.1038/ncomms9719
PubMed ID: 26515371
関連リンク: http://www.kyoto-u.ac.jp/ja/research/research_results/2015/151030_1.html
出現コレクション:学術雑誌掲載論文等

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