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dc.contributor.authorSon, Shurakuja
dc.contributor.authorKubota, Manabuja
dc.contributor.authorMiyata, Junja
dc.contributor.authorFukuyama, Hidenaoja
dc.contributor.authorAso, Toshihikoja
dc.contributor.authorUrayama, Shin-ichija
dc.contributor.authorMurai, Toshiyaja
dc.contributor.authorTakahashi, Hidehikoja
dc.contributor.alternative孫, 樹洛ja
dc.contributor.alternative高橋, 英彦ja
dc.description.abstractBoth creativity and schizotypy are suggested to be manifestations of the hyperactivation of unusual or remote concepts/words. However, the results of studies on creativity in schizophrenia are diverse, possibly due to the multifaceted aspects of creativity and difficulties of differentiating adaptive creativity from pathological schizotypy/positive symptoms. To date, there have been no detailed studies comprehensively investigating creativity, positive symptoms including delusions, and their neural bases in schizophrenia. In this study, we investigated 43 schizophrenia and 36 healthy participants using diffusion tensor imaging. We used idea, design, and verbal (semantic and phonological) fluency tests as creativity scores and Peters Delusions Inventory as delusion scores. Subsequently, we investigated group differences in every psychological score, correlations between fluency and delusions, and relationships between these scores and white matter integrity using tract-based spatial statistics (TBSS). In schizophrenia, idea and verbal fluency were significantly lower in general, and delusion score was higher than in healthy controls, whereas there were no group differences in design fluency. We also found positive correlation between phonological fluency and delusions in schizophrenia. By correlation analyses using TBSS, we found that the anterior part of corpus callosum was the substantially overlapped area, negatively correlated with both phonological fluency and delusion severity. Our results suggest that the anterior interhemispheric dysconnectivity might be associated with executive dysfunction, and disinhibited automatic spreading activation in the semantic network was manifested as uncontrollable phonological fluency or delusions. This dysconnectivity could be one possible neural basis that differentiates pathological positive symptoms from adaptive creativity.ja
dc.publisherElsevier B.V.ja
dc.rights© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
dc.rightsThe full-text file will be made open to the public on 31 May 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.ja
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.ja
dc.subjectAutomatic spreading activationja
dc.subjectPhonological fluencyja
dc.subjectInterhemispheric dysconnectivityja
dc.subjectExecutive dysfunctionja
dc.subjectCorpus callosumja
dc.titleCreativity and positive symptoms in schizophrenia revisited: Structural connectivity analysis with diffusion tensor imaging.ja
dc.type.niitypeJournal Articleja
dc.identifier.jtitleSchizophrenia researchja
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