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タイトル: | Preoperative intramuscular adipose tissue content is a novel prognostic predictor after hepatectomy for hepatocellular carcinoma. |
著者: | Hamaguchi, Yuhei Kaido, Toshimi Okumura, Shinya Ito, Takashi Fujimoto, Yasuhiro Ogawa, Kohei Mori, Akira Hammad, Ahmed Hatano, Etsuro Uemoto, Shinji |
著者名の別形: | 海道, 利実 |
キーワード: | Hepatocellular carcinoma Intramuscular adipose tissue content Prognostic factor Sarcopenia |
発行日: | 5-Mar-2015 |
出版者: | wiley |
誌名: | Journal of hepato-biliary-pancreatic sciences |
巻: | 22 |
号: | 6 |
開始ページ: | 475 |
終了ページ: | 485 |
抄録: | [Background] Sarcopenia has been shown to be an independent predictor of lower disease-free and overall survival in various kinds of diseases. The quality of skeletal muscle has recently attracted much attention as a new parameter of sarcopenia. [Methods] We performed a retrospective analysis of 477 patients undergoing hepatectomy for hepatocellular carcinoma (HCC) between April 2005 and August 2014. The quality of skeletal muscle was evaluated by intramuscular adipose tissue content (IMAC) using preoperative computed tomography (CT) imaging. The impact of IMAC on outcomes after hepatectomy for HCC was analyzed. [Results] Patients with high IMAC showed older age, higher body mass index, higher indocyanine green retention test at 15 min, and more operative blood loss. The overall and recurrence-free survival rates were significantly lower in patients with high IMAC than in patients with normal IMAC (P < 0.0001, P = 0.0012, respectively). Multivariate analysis showed that high IMAC was the significant risk factor for death (hazard ratio [HR] = 2.942; P < 0.0001) and for HCC recurrence (HR = 1.529; P = 0.0007) after hepatectomy. [Conclusions] Preoperative quality of skeletal muscle was closely correlated with postoperative mortality and HCC recurrence. IMAC could be incorporated into new selection criteria for hepatectomy for HCC. |
著作権等: | This is the peer reviewed version of the following article: Hamaguchi, Y, Kaido, T, Okumura, S, Ito, T, Fujimoto, Y, Ogawa, K, Mori, A, Hammad, A, Hatano, E, and Uemoto, S (2015), Preoperative intramuscular adipose tissue content is a novel prognostic predictor after hepatectomy for hepatocellular carcinoma. J Hepatobiliary Pancreat Sci, 22, 475–485, which has been published in final form at http://dx.doi.org/10.1002/jhbp.236. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. The full-text file will be made open to the public on 5 March 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/201493 |
DOI(出版社版): | 10.1002/jhbp.236 |
PubMed ID: | 25755128 |
出現コレクション: | 学術雑誌掲載論文等 |
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