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Title: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful?
Authors: Kakigi, Takahide
Okada, Tomohisa  kyouindb  KAKEN_id  orcid (unconfirmed)
Kanagaki, Mitsunori
Yamamoto, Akira  kyouindb  KAKEN_id  orcid (unconfirmed)
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid (unconfirmed)
Sakamoto, Ryo
Arakawa, Yoshiki  kyouindb  KAKEN_id  orcid (unconfirmed)
Mikami, Yoshiki
Shimono, Taro
Takahashi, Jun C
Togashi, Kaori  kyouindb  KAKEN_id
Author's alias: 柿木, 崇秀
岡田, 知久
Keywords: Pineal tumor
CT attenuation
Apparent diffusion coefficient
Standardized uptake value
Issue Date: 9-Feb-2014
Publisher: Springer Berlin Heidelberg
Journal title: Neuroradiology
Volume: 56
Issue: 4
Start page: 297
End page: 303
Abstract: [Introduction] Quantitative values of CT attenuation, apparent diffusion coefficient (ADC), and standardized uptake value (SUV) were investigated for differentiation between pineal parenchymal tumors (PPTs) and germinomas. Differences in age, sex, and calcification pattern were also evaluated. [Methods] Twenty-three patients with PPTs and germinomas in 20 years were retrospectively enrolled under the approval of the institutional review board. CT attenuation, ADC, and SUV (20, 13, and 10 patients, respectively) were statistically compared between the two tumors. Differences in sex and patterns of calcification (“exploded" or “engulfed") were also examined. Mean patient ages were compared among three groups of pineoblastoma, pineal parenchymal tumor of intermediate differentiation, (PPTID) and pineocytoma and germinoma. [Results]None of the quantitative values of CT attenuation, ADC, and SUV showed significant differences between PPTs and germinomas (p > .05). However, there was a significant difference in age (p < .05) among the three groups of pineoblastoma (mean age ± standard deviation 7.0 ± 8.7 years), PPTID, and pineocytoma (53.7 ± 11.4 years) and germinoma (19.1 ± 8.1 years). Sex also showed significant differences between PPTs and germinomas (p = .039). Exploded pattern of calcification was found in 9 of 11 PPT patients and engulfed pattern in 7 of 9 patients with germinomas. No reverse pattern was observed, and the patterns of calcification were considered highly specific of tumor types.[Conclusions] None of the quantitative imaging values could differentiate PPTs from germinomas. Age, sex, and calcification patterns were confirmed useful in differentiating these tumors to some degree.
Rights: The final publication is available at Springer via
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1007/s00234-014-1334-2
PubMed ID: 24510202
Appears in Collections:Journal Articles

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