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Title: A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts.
Authors: Syed, Junetha
Chandran, Anandhakumar
Pandian, Ganesh N
Taniguchi, Junichi
Sato, Shinsuke
Hashiya, Kaori
Kashiwazaki, Gengo
Bando, Toshikazu
Sugiyama, Hiroshi  kyouindb  KAKEN_id
Author's alias: 杉山, 弘
Keywords: artificial transcription activators
DNA recognition
gene expression
histone acetylation
transcription profiling
Issue Date: 28-May-2015
Publisher: wiley
Journal title: Chembiochem
Volume: 16
Issue: 10
Start page: 1497
End page: 1501
Abstract: Small molecules capable of modulating epigenetic signatures can activate the transcription of tissue-restricted genes in a totally unrelated cell type and have potential use in epigenetic therapy. To provide an example for an initial approach, we report here on one synthetic small-molecule compound-termed "SAHA-PIP X"-from our library of conjugates. This compound triggered histone acetylation accompanied by the transcription of retinal-tissue-related genes in human dermal fibroblasts (HDFs).
Rights: This is the peer reviewed version of the following article: Syed, J., Chandran, A., Pandian, G. N., Taniguchi, J., Sato, S., Hashiya, K., Kashiwazaki, G., Bando, T. and Sugiyama, H. (2015), A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts. ChemBioChem, 16: 1497–1501, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
The full-text file will be made open to the public on 28 May 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1002/cbic.201500140
PubMed ID: 25900774
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