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|Title:||A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts.|
Pandian, Ganesh N
|Author's alias:||杉山, 弘|
|Keywords:||artificial transcription activators|
|Abstract:||Small molecules capable of modulating epigenetic signatures can activate the transcription of tissue-restricted genes in a totally unrelated cell type and have potential use in epigenetic therapy. To provide an example for an initial approach, we report here on one synthetic small-molecule compound-termed "SAHA-PIP X"-from our library of conjugates. This compound triggered histone acetylation accompanied by the transcription of retinal-tissue-related genes in human dermal fibroblasts (HDFs).|
|Rights:||This is the peer reviewed version of the following article: Syed, J., Chandran, A., Pandian, G. N., Taniguchi, J., Sato, S., Hashiya, K., Kashiwazaki, G., Bando, T. and Sugiyama, H. (2015), A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts. ChemBioChem, 16: 1497–1501, which has been published in final form at http://dx.doi.org/10.1002/cbic.201500140. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.|
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|Appears in Collections:||Journal Articles|
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