Downloads: 174

Files in This Item:
File Description SizeFormat 
j.tet.2015.04.050.pdf303.68 kBAdobe PDFView/Open
Title: Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents
Authors: Miyake, Yuka
Kimura, Yu  kyouindb  KAKEN_id  orcid (unconfirmed)
Orito, Naomi
Imai, Hirohiko  kyouindb  KAKEN_id
Matsuda, Tetsuya  kyouindb  KAKEN_id  orcid (unconfirmed)
Toshimitsu, Akio
Kondo, Teruyuki
Author's alias: 近藤, 輝幸
Keywords: Chiral dendrimer
MRI contrast agent
Polyethylene glycol
Molecular imaging
Issue Date: 1-Jul-2015
Publisher: Elsevier Ltd.
Journal title: Tetrahedron
Volume: 71
Issue: 26-27
Start page: 4438
End page: 4444
Abstract: Novel chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups were synthesized and shown to have longitudinal relaxivity (r1) values 5 times higher than that of clinically used Gd-DTPA. The affinities of Gd-4a and Gd-4b for bovine serum albumin (BSA), respectively, were estimated by a quartz crystal microbalance (QCM) measurement. The amino groups of the dendrimer were then conjugated with PEG. This conjugation with PEG strongly affected its ability to attenuate signals in T1-weighted MRI.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
The full-text file will be made open to the public on 1 July 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.tet.2015.04.050
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks

Export Format: 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.