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Title: Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents
Authors: Miyake, Yuka
Kimura, Yu  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5318-9255 (unconfirmed)
Orito, Naomi
Imai, Hirohiko  kyouindb  KAKEN_id
Matsuda, Tetsuya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-2339-1521 (unconfirmed)
Toshimitsu, Akio
Kondo, Teruyuki
Author's alias: 近藤, 輝幸
Keywords: Chiral dendrimer
MRI contrast agent
Gadolinium
Polyethylene glycol
Molecular imaging
Issue Date: 1-Jul-2015
Publisher: Elsevier Ltd.
Journal title: Tetrahedron
Volume: 71
Issue: 26-27
Start page: 4438
End page: 4444
Abstract: Novel chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups were synthesized and shown to have longitudinal relaxivity (r1) values 5 times higher than that of clinically used Gd-DTPA. The affinities of Gd-4a and Gd-4b for bovine serum albumin (BSA), respectively, were estimated by a quartz crystal microbalance (QCM) measurement. The amino groups of the dendrimer were then conjugated with PEG. This conjugation with PEG strongly affected its ability to attenuate signals in T1-weighted MRI.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
The full-text file will be made open to the public on 1 July 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/201952
DOI(Published Version): 10.1016/j.tet.2015.04.050
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