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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.tet.2015.04.050.pdf | 303.68 kB | Adobe PDF | 見る/開く |
| タイトル: | Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents |
| 著者: | Miyake, Yuka Kimura, Yu    https://orcid.org/0000-0001-5318-9255 (unconfirmed)Orito, Naomi Imai, Hirohiko Matsuda, Tetsuya https://orcid.org/0000-0002-2339-1521 (unconfirmed)Toshimitsu, Akio Kondo, Teruyuki |
| 著者名の別形: | 近藤, 輝幸 |
| キーワード: | Chiral dendrimer MRI contrast agent Gadolinium Polyethylene glycol Molecular imaging |
| 発行日: | 1-Jul-2015 |
| 出版者: | Elsevier Ltd. |
| 誌名: | Tetrahedron |
| 巻: | 71 |
| 号: | 26-27 |
| 開始ページ: | 4438 |
| 終了ページ: | 4444 |
| 抄録: | Novel chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups were synthesized and shown to have longitudinal relaxivity (r1) values 5 times higher than that of clinically used Gd-DTPA. The affinities of Gd-4a and Gd-4b for bovine serum albumin (BSA), respectively, were estimated by a quartz crystal microbalance (QCM) measurement. The amino groups of the dendrimer were then conjugated with PEG. This conjugation with PEG strongly affected its ability to attenuate signals in T1-weighted MRI. |
| 著作権等: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ The full-text file will be made open to the public on 1 July 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/201952 |
| DOI(出版社版): | 10.1016/j.tet.2015.04.050 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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