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j.tet.2015.04.050.pdf | 303.68 kB | Adobe PDF | 見る/開く |
タイトル: | Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents |
著者: | Miyake, Yuka Kimura, Yu ![]() ![]() ![]() Orito, Naomi Imai, Hirohiko ![]() ![]() ![]() Matsuda, Tetsuya ![]() ![]() Toshimitsu, Akio Kondo, Teruyuki ![]() ![]() |
著者名の別形: | 近藤, 輝幸 |
キーワード: | Chiral dendrimer MRI contrast agent Gadolinium Polyethylene glycol Molecular imaging |
発行日: | 1-Jul-2015 |
出版者: | Elsevier Ltd. |
誌名: | Tetrahedron |
巻: | 71 |
号: | 26-27 |
開始ページ: | 4438 |
終了ページ: | 4444 |
抄録: | Novel chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups were synthesized and shown to have longitudinal relaxivity (r1) values 5 times higher than that of clinically used Gd-DTPA. The affinities of Gd-4a and Gd-4b for bovine serum albumin (BSA), respectively, were estimated by a quartz crystal microbalance (QCM) measurement. The amino groups of the dendrimer were then conjugated with PEG. This conjugation with PEG strongly affected its ability to attenuate signals in T1-weighted MRI. |
著作権等: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ The full-text file will be made open to the public on 1 July 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/201952 |
DOI(出版社版): | 10.1016/j.tet.2015.04.050 |
出現コレクション: | 学術雑誌掲載論文等 |
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