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タイトル: | Dopamine in socioecological and evolutionary perspectives: implications for psychiatric disorders. |
著者: | Yamaguchi, Yoshie Lee, Young-A Goto, Yukiori ![]() ![]() |
著者名の別形: | 後藤, 幸織 |
キーワード: | primates social hierarchy social interaction evolution dopamine psychiatric disorder genetic variants |
発行日: | 16-Jun-2015 |
出版者: | Frontiers |
誌名: | Frontiers in neuroscience |
巻: | 9 |
論文番号: | 219 |
抄録: | Dopamine (DA) transmission in brain areas such as the prefrontal cortex (PFC) and nucleus accumbens (NAcc) plays important roles in cognitive and affective function. As such, DA deficits have been implicated in a number of psychiatric disorders such as schizophrenia and attention deficit/hyperactivity disorder (ADHD). Accumulating evidence suggests that DA is also involved in social behavior of animals and humans. Although most animals organize and live in social groups, how the DA system functions in such social groups of animals, and its dysfunction causes compromises in the groups has remained less understood. Here we propose that alterations of DA signaling and associated genetic variants and behavioral phenotypes, which have been normally considered as "deficits" in investigation at an individual level, may not necessarily yield disadvantages, but even work advantageously, depending on social contexts in groups. This hypothesis could provide a novel insight into our understanding of the biological mechanisms of psychiatric disorders, and a potential explanation that disadvantageous phenotypes associated with DA deficits in psychiatric disorders have remained in humans through evolution. |
著作権等: | © 2015 Yamaguchi, Lee and Goto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
URI: | http://hdl.handle.net/2433/201966 |
DOI(出版社版): | 10.3389/fnins.2015.00219 |
PubMed ID: | 26136653 |
出現コレクション: | 学術雑誌掲載論文等 |
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