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Title: Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor.
Authors: Abe, Kentaro
Matsui, Sumiko
Watanabe, Dai  kyouindb  KAKEN_id
Author's alias: 安部, 健太郎
Keywords: songbird
CREB
transgenic animal
vocal learning
postnatal development
Issue Date: 16-Jun-2015
Publisher: National Academy of Sciences
Journal title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 112
Issue: 24
Start page: 7599
End page: 7604
Abstract: Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning.
Rights: © 2015 National Academy of Sciences.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/201976
DOI(Published Version): 10.1073/pnas.1413484112
PubMed ID: 26048905
Appears in Collections:Journal Articles

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