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Title: Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models.
Authors: So, Kanako
Haraguchi, Kayo
Asakura, Kayoko
Isami, Koichi
Sakimoto, Shinya
Shirakawa, Hisashi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-4129-0978 (unconfirmed)
Mori, Yasuo  kyouindb  KAKEN_id
Nakagawa, Takayuki  kyouindb  KAKEN_id
Kaneko, Shuji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5152-5809 (unconfirmed)
Author's alias: 中川, 貴之
Keywords: TRPM2
Inflammatory pain
Neuropathic pain
Pain models
Knockout mice
Issue Date: Mar-2015
Publisher: Japanese Pharmacological Society
Journal title: Journal of pharmacological sciences
Volume: 127
Issue: 3
Start page: 237
End page: 243
Abstract: Recent evidence suggests a role of transient receptor potential melastatin 2 (TRPM2) in immune and inflammatory responses. We previously reported that TRPM2 deficiency attenuated inflammatory and neuropathic pain in some pain mouse models, including formalin- or carrageenan-induced inflammatory pain, and peripheral nerve injury-induced neuropathic pain models, while it had no effect on the basal mechanical and thermal nociceptive sensitivities. In this study, we further explored the involvement of TRPM2 in various pain models using TRPM2-knockout mice. There were no differences in the chemonociceptive behaviors evoked by intraplantar injection of capsaicin or hydrogen peroxide between wildtype and TRPM2-knockout mice, while acetic acid-induced writhing behavior was significantly attenuated in TRPM2-knockout mice. In the postoperative incisional pain model, no difference in mechanical allodynia was observed between the two genotypes. By contrast, mechanical allodynia in the monosodium iodoacetate-induced osteoarthritis pain model and the experimental autoimmune encephalomyelitis model were significantly attenuated in TRPM2-knockout mice. Furthermore, mechanical allodynia in paclitaxel-induced peripheral neuropathy and streptozotocin-induced painful diabetic neuropathy models were significantly attenuated in TRPM2-knockout mice. Taken together, these results suggest that TRPM2 plays roles in a wide range of pathological pain models based on peripheral and central neuroinflammation, rather than physiological nociceptive pain.
Rights: © 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/201978
DOI(Published Version): 10.1016/j.jphs.2014.10.003
PubMed ID: 25837919
Appears in Collections:Journal Articles

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