ダウンロード数: 265
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.jphs.2014.10.003.pdf | 1.14 MB | Adobe PDF | 見る/開く |
タイトル: | Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models. |
著者: | So, Kanako Haraguchi, Kayo Asakura, Kayoko Isami, Koichi Sakimoto, Shinya Shirakawa, Hisashi https://orcid.org/0000-0002-4129-0978 (unconfirmed) Mori, Yasuo Nakagawa, Takayuki https://orcid.org/0000-0003-1890-0843 (unconfirmed) Kaneko, Shuji https://orcid.org/0000-0001-5152-5809 (unconfirmed) |
著者名の別形: | 中川, 貴之 |
キーワード: | TRPM2 Inflammatory pain Neuropathic pain Pain models Knockout mice |
発行日: | Mar-2015 |
出版者: | Japanese Pharmacological Society |
誌名: | Journal of pharmacological sciences |
巻: | 127 |
号: | 3 |
開始ページ: | 237 |
終了ページ: | 243 |
抄録: | Recent evidence suggests a role of transient receptor potential melastatin 2 (TRPM2) in immune and inflammatory responses. We previously reported that TRPM2 deficiency attenuated inflammatory and neuropathic pain in some pain mouse models, including formalin- or carrageenan-induced inflammatory pain, and peripheral nerve injury-induced neuropathic pain models, while it had no effect on the basal mechanical and thermal nociceptive sensitivities. In this study, we further explored the involvement of TRPM2 in various pain models using TRPM2-knockout mice. There were no differences in the chemonociceptive behaviors evoked by intraplantar injection of capsaicin or hydrogen peroxide between wildtype and TRPM2-knockout mice, while acetic acid-induced writhing behavior was significantly attenuated in TRPM2-knockout mice. In the postoperative incisional pain model, no difference in mechanical allodynia was observed between the two genotypes. By contrast, mechanical allodynia in the monosodium iodoacetate-induced osteoarthritis pain model and the experimental autoimmune encephalomyelitis model were significantly attenuated in TRPM2-knockout mice. Furthermore, mechanical allodynia in paclitaxel-induced peripheral neuropathy and streptozotocin-induced painful diabetic neuropathy models were significantly attenuated in TRPM2-knockout mice. Taken together, these results suggest that TRPM2 plays roles in a wide range of pathological pain models based on peripheral and central neuroinflammation, rather than physiological nociceptive pain. |
著作権等: | © 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/201978 |
DOI(出版社版): | 10.1016/j.jphs.2014.10.003 |
PubMed ID: | 25837919 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。