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dc.contributor.authorNishikori, Momokoja
dc.contributor.authorKitano, Toshiyukija
dc.contributor.authorKobayashi, Masayukija
dc.contributor.authorHishizawa, Masakatsuja
dc.contributor.authorKitawaki, Toshioja
dc.contributor.authorKondo, Tadakazuja
dc.contributor.authorYamashita, Kouheija
dc.contributor.authorKawabata, Hiroshija
dc.contributor.authorKadowaki, Norimitsuja
dc.contributor.authorTakei, Yusukeja
dc.contributor.authorHaga, Hironorija
dc.contributor.authorTakaori-Kondo, Akifumija
dc.contributor.alternative錦織, 桃子ja
dc.date.accessioned2015-12-02T07:39:17Z-
dc.date.available2015-12-02T07:39:17Z-
dc.date.issued2015-07ja
dc.identifier.issn0925-5710ja
dc.identifier.urihttp://hdl.handle.net/2433/202063-
dc.descriptionFirst online: 02 April 2015ja
dc.description.abstractBendamustine is a chemotherapeutic drug that has recently come to be used frequently in the treatment of indolent B cell lymphomas. Skin toxicity is recognized as one of its characteristic side effects, but detailed information on such reactions has not yet been obtained. To clarify the clinical features of skin toxicity associated with bendamustine, we retrospectively analyzed skin reactions that developed in patients treated with bendamustine and rituximab (BR). Of 34 patients treated with 3-6 cycles of BR, 11 developed late-onset, persistent skin eruptions. These patients demonstrated increases in CD8(+) T cell number and CD8(+):CD4(+) cell ratio at the end of chemotherapy. In contrast, peripheral eosinophil count was not associated with such adverse events, whereas eosinophil infiltration was frequently observed in the skin. Patients with skin reactions tended to have higher seropositivity of hepatitis B core antibody, and multiplex viral screening PCR of the frozen sera demonstrated cytomegalovirus-DNA in some of the eruption-positive patients. It is speculated that inappropriate activation of CD8(+) T cells by latently infected pathogens may be one of the triggers of late-onset skin reactions caused by bendamustine.ja
dc.format.mimetypeapplication/pdfja
dc.language.isoengja
dc.publisherSpringer Japanja
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s12185-015-1791-3.ja
dc.rightsThe full-text file will be made open to the public on 02 April 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.ja
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.ja
dc.subjectBendamustineja
dc.subjectSkin reactionsja
dc.subjectCD8(+) T cellsja
dc.subjectCytomegalovirusja
dc.titleIncreased number of peripheral CD8(+) T cells but not eosinophils is associated with late-onset skin reactions caused by bendamustine.ja
dc.type.niitypeJournal Articleja
dc.identifier.ncidAA10797094ja
dc.identifier.jtitleInternational journal of hematologyja
dc.identifier.volume102ja
dc.identifier.issue1ja
dc.identifier.spage53ja
dc.identifier.epage58ja
dc.relation.doi10.1007/s12185-015-1791-3ja
dc.textversionauthorja
dc.startdate.bitstreamsavailable2016-04-02ja
dc.identifier.pmid25833722ja
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