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Title: Increased bone marrow uptake of 18F-FDG in leukemia patients: preliminary findings.
Authors: Arimoto, Maya Kato
Nakamoto, Yuji
Nakatani, Koya
Ishimori, Takayoshi  kyouindb  KAKEN_id
Yamashita, Kouhei
Takaori-Kondo, Akifumi
Togashi, Kaori
Author's alias: 中本, 裕士
Keywords: Leukemia
Bone marrow
18F-FDG PET/CT
Issue Date: 17-Sep-2015
Publisher: SpringerOpen
Journal title: SpringerPlus
Volume: 4
Thesis number: 521
Abstract: The aim of this retrospective study was to evaluate the characteristics of increased bone marrow uptake of 18F-FDG in patients with leukemia who underwent whole-body 18F-FDG PET/CT. The 18F-FDG PET/CT images of 9 patients with histologically proven leukemia were reviewed. The accumulation of 18F-FDG in the bone marrow was evaluated, and was compared with histological subtype, clinical course, and hematological findings. Nine patients (4 males, 5 females; age range, 5-58 years) had increased bone marrow uptake of 18F-FDG, including 6 patients with acute lymphoblastic leukemia, 1 with acute myeloid leukemia, 1 with chronic myeloid leukemia, and 1 with mature B cell neoplasm. Bone marrow uptake was generally diffuse but focal or inhomogeneous uptake was common, especially in the upper and lower extremities. Patients with increased bone marrow uptake of 18F-FDG commonly complained of fever and bone pain. No correlations between 18F-FDG uptake and peripheral blood findings were observed. Patients with leukemia may have increased bone marrow uptake of 18F-FDG on PET/CT, possibly reflecting leukemic cell activity. Leukemia can be included in the differential diagnosis when increased bone marrow uptake of 18F-FDG is observed.
Rights: © 2015 Arimoto et al.
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
URI: http://hdl.handle.net/2433/202087
DOI(Published Version): 10.1186/s40064-015-1339-2
PubMed ID: 26405641
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