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Title: | Increased bone marrow uptake of 18F-FDG in leukemia patients: preliminary findings. |
Authors: | Arimoto, Maya Kato Nakamoto, Yuji https://orcid.org/0000-0001-5783-8048 (unconfirmed) Nakatani, Koya Ishimori, Takayoshi Yamashita, Kouhei Takaori-Kondo, Akifumi Togashi, Kaori |
Author's alias: | 中本, 裕士 |
Keywords: | Leukemia Bone marrow 18F-FDG PET/CT |
Issue Date: | 17-Sep-2015 |
Publisher: | SpringerOpen |
Journal title: | SpringerPlus |
Volume: | 4 |
Thesis number: | 521 |
Abstract: | The aim of this retrospective study was to evaluate the characteristics of increased bone marrow uptake of 18F-FDG in patients with leukemia who underwent whole-body 18F-FDG PET/CT. The 18F-FDG PET/CT images of 9 patients with histologically proven leukemia were reviewed. The accumulation of 18F-FDG in the bone marrow was evaluated, and was compared with histological subtype, clinical course, and hematological findings. Nine patients (4 males, 5 females; age range, 5-58 years) had increased bone marrow uptake of 18F-FDG, including 6 patients with acute lymphoblastic leukemia, 1 with acute myeloid leukemia, 1 with chronic myeloid leukemia, and 1 with mature B cell neoplasm. Bone marrow uptake was generally diffuse but focal or inhomogeneous uptake was common, especially in the upper and lower extremities. Patients with increased bone marrow uptake of 18F-FDG commonly complained of fever and bone pain. No correlations between 18F-FDG uptake and peripheral blood findings were observed. Patients with leukemia may have increased bone marrow uptake of 18F-FDG on PET/CT, possibly reflecting leukemic cell activity. Leukemia can be included in the differential diagnosis when increased bone marrow uptake of 18F-FDG is observed. |
Rights: | © 2015 Arimoto et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
URI: | http://hdl.handle.net/2433/202087 |
DOI(Published Version): | 10.1186/s40064-015-1339-2 |
PubMed ID: | 26405641 |
Appears in Collections: | Journal Articles |
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